Circulate Bundle

What Is the Circulate Bundle?

The Circulate Bundle replaces Olympia’s Circulate IV premix with two separate compounded injections: Arginine Injection 200mg/mL and Pyridoxine (Vitamin B6) Injection 85mg/mL. Because each product comes in its own vial, your provider can determine the dose and route for each one.

What’s Included

Arginine Injection 200mg/mL

Arginine, also known as L-arginine, is an amino acid that is a building block for proteins. It is naturally produced in the body and found in foods like red meat, poultry, fish, dairy and eggs. The body converts arginine into nitric oxide, which helps relax the muscles that constrict blood vessels.

Pyridoxine (Vitamin B6) Injection 85mg/mL

Pyridoxine, more commonly known as vitamin B6, is an essential nutrient the body can’t produce on its own. Once in the body, it is converted into its active form, pyridoxal phosphate (PLP), which is involved in amino acid metabolism, neurotransmitter production and the production of hemoglobin, the oxygen-carrying protein in red blood cells.

Dosis, concentración y vía de administración

• Dosage: Seek advice from a licensed physician, medical director or other healthcare provider
• Concentrations: Arginine 200mg/mL; Pyridoxine 85mg/mL
• Route of administration: IV/IM/SQ (both products)

Resources: How to Open Your Medication Vial

Precautions and Side Effects

Arginine: The effects of L-arginine during pregnancy or breastfeeding are not well understood, so caution is advised. Special precautions should be taken by people with asthma, allergies, cirrhosis, herpes, low blood pressure, a recent heart attack or kidney disease. Because arginine can affect blood pressure, people anticipating surgery should stop using it at least two weeks beforehand. Arginine can interact with medications. Common side effects can include abdominal pain, bloating, diarrhea, allergies, worsening of asthma and low blood pressure.

Pyridoxine (Vitamin B6): Pyridoxine can interact with medications, including altretamine, barbiturates, fosphenytoin, phenytoin and levodopa. At recommended doses it usually has no side effects. Large doses taken over a long period may cause headache, nausea, drowsiness, or numbness or tingling in the arms and legs. Seek immediate medical attention for rash, itching, swelling, severe dizziness or trouble breathing.

Always share a list of your current medications with your provider.

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