TriMix Injections

TriMix is a prescribed, injectable medication that is self-administered and consists of three active ingredients: alprostadil, papaverine and phentolamine.


Dosage Strength & Concentration

  • Dosage: Varies by patient — please follow instructions provided by your physician
  • Concentration: Varied by formulation
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TriMix is a prescribed, injectable medication consisting of three active ingredients: alprostadil, papaverine and phentolamine. Together, these three medications help to relax, expand, and fill the corpus cavernosum (erectile tissue) with blood resulting in an erection shortly after administration. Unlike oral medications, TriMix injections are localized to the intended area rather than having to flow through the bloodstream into other areas of the body. TriMix injections are self-administered and can be performed quickly and easily from the comfort of your own home.

What Is Trimix Prescribed For?

TriMix is indicated in the treatment of males with erectile dysfunction. This injectable medication is indicated for patients who are unable to safely take, or who have not had good results from PDE5 inhibitors. Trimix provides satisfactory results in up to 90% of patients.

Dosage, Concentration, Route of Administration

Dosage: Varies by patient — please follow instructions provided by your physician

Concentration: Varied by formulation

Route of Administration: Penile injection

Precautions/Side Effects

The use of TriMix injections is contraindicated in patients with allergies to any components in this medication, sickle cell anemia, blood clotting disorders, any condition that can predispose you to priapism (a painful erection lasting more than 4 hours), leukemia, anatomical deformations of the penis, penile implants, and if you have direct instructions from your physician to abstain from sexual activity.

It is important to provide your healthcare provider with a list of all drugs that you are currently using. This includes all non-prescription drugs, illegal drugs, herbal, and dietary supplements. Some chemicals within TriMix can interact with your medication causing them to become ineffective or leave you with adverse effects. Please consult your physician for personalized dosing directions and concerns about interactions with other medications.

Some common side effects include:

  • Pain: This is very minimal though as there are not many nerve endings in the area of injection.
  • Bleeding: This could be due to the angle administered or may result from hitting a tiny blood vessel. If this occurs, apply pressure until bleeding has stopped. Do not engage in sexual activity until bleeding has ceased.
  • Infection: Good hygiene always prevents this. Make sure the area is clean and use alcohol swabs just prior to administering the injection. Always be sure to wash your hands before and after administration.
  • Priapism: This can be a painful erection lasting longer than 4 hours. This is a medical emergency. If unseen, the tissue can become damaged, and the effects may be irreversible. If your erection lasts for more than 2 hours, take 2 – 4 pseudoephedrine tablets only once. You should then apply an ice pack. If this erection persists after another hour, seek immediate medical attention.

While using TriMix, if you experience any swelling, numbness, tenderness, redness, and lumps on your penis or its surrounding areas, make sure to contact your provider immediately.


Trimix is to be stored refrigerated or frozen.

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