What Are GLP-1 Agonists?

GLP-1 agonists are a class of drugs primarily used for managing type 2 diabetes that have also proven effective for weight loss. These medications work by mimicking the actions of the glucagon-like peptide-1 hormone, aiding in blood sugar regulation and promoting a feeling of fullness. Common examples of GLP-1 agonist medications include:

Prescribers and physicians: Access our GLP-1 order form here:

Download the Order Form

If you’re a patient, learn more about our weight management solutions now:

Get Started
A person's abdomen with a gray and blue Ozempic pen injecting semaglutide. Waves background

How Do GLP-1 Agonists Help You Lose Weight?

GLP-1 agonists assist in weight loss by helping control overall calorie consumption. This is achieved in two key ways. Firstly, they slow gastric emptying, keeping food in the stomach longer and extending post-meal fullness. This reduces the urge to eat frequently or avoid excessive overeating.

Secondly, these medications positively impact the brain’s satiety centers, responsible for signaling when we are full. By stimulating these centers, GLP-1 agonists promote satisfaction with smaller food portions, further supporting reduced total calorie intake. Together, these enable GLP-1 agonists to be effective in weight loss strategies.


Understand the Clinical Evidence Supporting GLP-1 Agonists for Obesity

A 2011 study published in the British Medical Journal revealed that GLP-1 receptor agonists led to an average weight loss of 2.9 kg (approximately 6.4 lbs) in obese diabetic and non-diabetic individuals. Similarly, a 2021 review published in Advances in Therapy affirmed the weight reduction benefits of GLP-1 agonists like liraglutide and semaglutide.

A 2023 review of research published in the International Journal of Obesity showed significant reductions in body weight, BMI, and waist circumference, particularly highlighting semaglutide’s effectiveness. Complementing this, a review published in The American Journal of Clinical Nutrition shed light on the cardiovascular advantages of GLP-1 agonists, suggesting their role goes beyond weight management to reduce heart-related risks in obese patients.

These studies collectively demonstrate the potential of GLP-1 agonists as an effective tool in combating obesity, offering hope to those who struggle with weight management and associated health risks.


Are You a Good Candidate for GLP-1 Agonists for Weight Loss?

While GLP-1 agonists work well for controlling blood sugar and helping with weight loss, it’s important to remember that they aren’t suitable for everyone, including pregnant individuals or those with certain pre-existing health conditions, like a history of pancreatitis. GLPL-1 agonists are typically prescribed only for those patients with a BMI greater than 30.

It is critical to consult a healthcare professional to understand the benefits and risks of starting a GLP-1 agonist and determine if it fits you.


Frequently Asked Questions

Q: Can I get GLP-1 agonists over the counter?

A: They’re only available by prescription due to their specific medical uses and potential side effects, which require medical supervision.

Q: Who should not take semaglutide?

A: Semaglutide is not recommended for those with a history of certain thyroid cancers or genetic syndromes, as well as individuals with severe pancreatitis or gastrointestinal or kidney issues. Always consult with a healthcare provider before starting a new medication.

Q: How quickly do you lose weight on GLP-1 agonists?

A: Many patients observe changes occurring in a few weeks. However, significant results generally take several months. The exact timeline for weight loss will vary depending on diet, exercise and compliance.

Q: What side effects are associated with GLP-1 agonists?

A: Common side effects include nausea, vomiting, diarrhea, constipation and decreased appetite, with possible injection site reactions. Serious side effects like pancreatitis or kidney issues are less common.

Q: Can GLP-1 agonists be combined with other weight-loss medications?

A: Yes, but only under medical supervision. The safety and effectiveness of combining medications will depend on a patient’s individual health conditions and the specific medications involved.

Q: Do GLP-1 agonists help with conditions other than weight loss?

A: GLP-1 agonists were initially developed to manage type 2 diabetes, and some studies have shown evidence that they might have positive effects on cardiovascular health. Please consult with a medical professional to determine if they are appropriate for your condition.

Tackling the GLP-1 Receptor Agonist Shortage

Hands in blue surgical gloves holding Ozempic semaglutide injection pen.

Global shortages of GLP-1 receptor agonists have recently become a significant concern. This drug shortage has been particularly impactful because they are vital in treating individuals with type 2 diabetes and those looking to manage their weight effectively.

Olympia Pharmaceuticals has taken a proactive step to address the dire need for this medication by compounding GLP-1 agonists. Compounding involves creating medications tailored to specific patient needs, often used as an alternative when commercially available drugs are in short supply. By compounding GLP-1 agonists, Olympia Pharmaceuticals is addressing a critical gap in medication availability, ensuring that patients continue to have access to these essential drugs.