• TriMix is a mixture of papaverine, phentolamine, and alprostadil.

  • QuadMix adds a 4th ingredient, which is usually atropine.

  • Injection therapy is accepted by the AUA as a viable alternative to surgery when oral medications can not be used or do not produce satisfactory results.

  • TriMix is safe for people who take nitrates.

  • Safe, reliable, and affordable.

Buy Trimix Now
Trimix Injections
Image frame background waves
Waves background

Everything You Need To Know About

Trimix & Trimix Injections

TriMix Definition: TriMix is a common term used to describe a mixture of Papaverine, Phentolamine, and Alprostadil (PGE). Each of these drugs produce a vasodilating effect when injected into the penis. The TriMix injection is done using a very small needle, inserted into the proper area along the shaft of the penis, so the drug mixture is delivered into the corpus cavernosum. The mixture of drugs causes the corpus cavernosum to relax, dilate, and become filled with blood, producing an erection. TriMix injection therapy is recognized as a viable treatment for erectile dysfunction by the American Urological Society.

TriMix is generally an effective, low-cost treatment, especially for those patients who have not had good results, or experience moderate to severe side effects from PDE5 inhibitors, (Viagra®, Levitra®, Cialis®).

 TriMix injections offer a solution for ED that is:

  • – Safe
  • – Reliable
  • – Fast-acting
  • – Long-lasting
  • – More affordable than oral medications
  • – Not affected by alcohol consumption

TriMix medication can provide longer and fuller erections that may last through climax, allowing you to maintain and improve your sexual health! An intracavernous injection is the most effective non-surgical treatment for ED, according to the American Urologic Association. Penile injections, unlike most oral medications, can trigger an automatic erection in less than 5 minutes.

What Is Erectile Dysfunction?

So, what is erectile dysfunction, exactly? Erectile dysfunction is sexual dysfunction characterized by the inability to develop or maintain an erection sufficient for intercourse. While erectile dysfunction can affect men of any age, it is most common in men over the age of 40. Studies have estimated that the number of men suffering from erectile dysfunction in the United States is more than 30 million. Learn more about erectile dysfunction and penile injection medications today.

Symptoms and Causes

The inability to achieve or maintain an erection can affect a man at any time. It can happen once in a while, or more frequently, and there can be many different causes. Some common causes include:

  • Low testosterone
  • – Cardiovascular disease
  • – Diabetes
  • – Prostate issues
  • – Depression
  • – Anxiety
  • – Nerve/spinal cord damage
  • – Effects of taking medications

Treatment Options

Olympia compounds various forms of popular oral medications for erectile dysfunction, such as:

  • Sildenafil (compare to Viagra): Available in capsules or rapid dissolve tablets (dissolve under tongue)
  • Vardenafil (compare to Levitra): Available in capsules or rapid dissolve tablets (dissolve under tongue)
  • Tadalafil (compare to Cialis): Available in capsules or rapid dissolve tablets (dissolve under tongue)

Olympia also offers more than 40 combinations of TriMix, a popular penile injection therapy medication. Our TriMix medications are backed by a full stability study as well as cGMP testing of every batch.

Want answers to your TriMix injection questions? View our FAQs now:

See TriMix FAQs

TriMix Injection Benefits

Goals of TriMix Injection Treatment

The goal of our TriMix injection treatment plans is to provide men with a reliable, easy-to-use, safe method of achieving and maintaining an erection suitable for sexual relations. There are many benefits to using TriMix injections for ED, including they’re safe, effective, easy to store, long-lasting, easy to administer and more. Once you receive a prescription, or if you have additional questions, contact us.

Couple in Bed

Alternative to Tablets

TriMix injections are an alternative to PDE5 Inhibitor tablets (Viagra®, Levitra®, Cialis®) and most commonly include the mixture of three drugs; phentolamine, papaverine and alprostadil. These penile injections can be especially useful when patients are unable to take PDE5 Inhibitors because they are taking nitrates, certain beta blockers, or experience severe side effects from the oral medications.

7 Things to Know About TriMix Injections:

1. They are safe. All of our formulas undergo extensive third-party testing before being released to patients. The use of TriMix injections is a common and well-tolerated method of obtaining an erection, and it’s been used by men with symptoms of ED for more than 30 years. It’s especially useful to men with severe ED caused by high blood pressure, high cholesterol, smoking, diabetes and obesity.

2. They are effective. TriMix ED injections are incredibly effective. According to the American Urologic Association, intracavernous injections like TriMix are currently the most effective option for non-surgical ED treatment.

3. They act quickly. Unlike oral ED medications, TriMix injections trigger an automatic erection — most in 10 minutes or less. Some men may not begin to see the effect until after sexual foreplay has begun. In the beginning, we recommend using a lower dose to prevent prolonged erections. Your doctor may recommend adjusting your dosage after the initial exposure.

4. They are long-lasting. TriMix injections provide longer and fuller erections than most oral alternatives that can last all the way through the climax, helping men achieve improved sexual health and performance. Erections should last between one and two hours.

An erection, using TriMix or any other ED medication, should never last four or more hours. Erections that last more than four hours are considered a medical emergency. Please contact your local emergency room to be treated immediately if you are experiencing this symptom.

5. They are easy to self-administer. For some, the idea of penile injections may seem too painful to self-administer. However, for many who’ve tried TriMix, the process couldn’t be easier and more painless! Check out these simple self-injection instructions to see how easy it can be to do yourself:

— Wash your hands with soap and water and keep the penis clean.
— Keep the TriMix cold and the syringe sterilized.
— The proper location for the injection is at the 9-11 and 1-3 o’clock positions between the base and mid-portion of the penis.
— Dispose of your needle properly after injection.

6. They aren’t affected by alcohol consumption. Unlike some medications, the effectiveness of TriMix injections is not normally altered by consuming alcohol. While using this medication, patients can drink responsibly and still have the same results as they would have without it.

7. They are easy to store. TriMix injections are best stored in the refrigerator (between 32 – 39°F) and should be kept away from light. If your prescription is for more than one vial of medication, please do the following items:

Store one TriMix vial at normal refrigeration temperature. This is the vial being actively used. For convenience, Olympia’s TriMix can be stored at room temperature for short periods of time while in use. However, every effort should be made to keep the medication refrigerated or frozen. When traveling, TriMix can be transported with an ice pack.

The remaining TriMix vials should be placed in a freezer and kept frozen. Frozen vials (between 0-31°F) have a beyond-use date of up to one year.

TriMix is shipped with ice packs. It is normal for the ice packs to melt and the medication to arrive unfrozen or even slightly warm. The effectiveness of the medication is not compromised. TriMix is shipped overnight to ensure stability and optimum results.

Download TriMix storage instructions here.
Buy TriMix Online

TriMix Injection Dosage

The initial Trimix Injection dose should be .05cc to .2cc, depending on each patient’s level of ED. Wait 48 hours before increasing dosage. Increase by 0.025 cc to 0.050 cc until a satisfactory dose is reached. The maximum dose is 0.50 cc. Do not be discouraged by a poor result with the first few injections, as the initial dose should be kept low to avoid a prolonged erection.

TriMix injection is a medication that is very customized to the patient’s needs. Olympia will work together with the physician and patient to develop a TriMix injection formula that is most effective for the individual patient.

To Prescribe TriMix Injections:

  • – Download and print the TriMix Prescription Form.
  • – Fax the signed and completed prescription form to Olympia (407-673-1234).
  • – Olympia will ship directly to the patient.

We support physicians and have more than 35 years of compounding expertise. We provide custom formulation and custom dosing to fit your needs.

View Our Information For Physicians

For other inquiries, including dosing information, please call our physician hotline at 407-673-2222 or email us at sales@olympiapharmacy.com.

Trimix Injection Instructions

Use this helpful video for complete instructions on how to properly inject TriMix medication or click the instructions linked below:

Download TriMix Injection Instructions

In this video, we’re going to show you how to properly inject TriMix medication.

Inside of the brown bottle, you’ll find the antidote to the medication, which is called Phenylephrine. Inside the clear bottle, you’ll find the TriMix medication.

To get started, you’ll want to remove the syringe from the packaging. There’s a protective cap over the needle on the syringe, and there’s also a protective cap on the back of the syringe. You’ll use the alcohol prep pad to clean the top of the vial as well as the injection site. On the top of the TriMix vial, there’s a protective seal. You’ll want to remove the protective seal and expose the rubber membrane.

Open the alcohol prep pad and use it to clean the rubber membrane on the top of the TriMix vial. Remove the cap on the back of the syringe, exposing the plunger.

Then, remove the front cap and expose the needle. Before you place the syringe inside the vial, you’ll want to draw back the same amount of units you’ve been prescribed to inject. In this case, we’re going to draw up 20 units into the syringe.

Insert the syringe into the vial through the rubber membrane. You’ll want to press down on the plunger and push the air into the vial. You’ll then want to slowly draw back the required amount of units into the syringe. Pull the syringe straight out of the vial, set the vial down, and then re-cap the front of the syringe.

The area of the penis that you’re injecting the medication into is called the corpus cavernosum. The corpus cavernosum runs on either side of the penis. You’ll want to make sure to inject at the 10 o’clock or 2 o’clock position. Do not inject on the same side each time you use the medication. You’ll want to make sure that you’re alternating sides between usage. This diagram shows where the corpus cavernosum is located inside the penis.

Before you apply the medication, you’ll want to clean the area of injection with the alcohol prep pad. As you go to apply the medication, make sure that you don’t pull on the penis or twist the penis in any way, because this may affect the injection site.

Now, you’re ready to apply the medication. You’ll want to remove the cap, and in one swift motion, you’ll apply the medication. Make sure that you avoid any veins. Pull the syringe straight out of the penis.

After injecting, you’ll want to apply pressure to the injection site. You’ll then want to massage the area of entry for about one minute and allow the medication to spread evenly throughout the entire penis.

To give you an idea of the amount of pressure you’ll want to apply to the plunger when you go to administer the medication, try drawing up water into one of the syringes. You’ll place your thumb on the back of the plunger and lightly press on the back of the plunger. This is the same amount of pressure you’ll want to apply to the plunger when you go to inject the TriMix medication. If you find that you have to apply more pressure than this, then you may not be in the corpus cavernosum, which means the medication will not be effective.

If you experience an erection lasting longer than two hours, you’ll want to apply the antidote to the medication, which is called Phenylephrine. You’ll apply the Phenylephrine the same way you apply the TriMix medication. First, draw up air into the syringe, and then insert the syringe into the vial of Phenylephrine. Slowly draw back 50 units of Phenylephrine into the syringe. Pull the syringe straight out of the vial and then re-cap the front of the syringe. You’ll want to inject one inch above the base of the penis at the 10 o’clock or 2 o’clock position. You want to make sure that you avoid any veins. And again, you’ll want to massage the area of entry for about one minute right after you administer the medication.

Thank you for watching. If you have any questions or concerns, email us directly at trimix@olympiapharmacy.com.

How to Get TriMix

Are You a Physician?

We support physicians and have more than 35 years of compounding expertise. We provide custom formulation and custom dosing to fit your needs.

To prescribe TriMix injections for patients:

  1. Download and print the TriMix Prescription Form.
  2. Fill out and fax the signed prescription form to Olympia Pharmacy at 407-673-1234.
  3. Olympia will ship injections directly to the patient.
Download Form

Are You a Patient?

While our erectile dysfunction medications do require a prescription from a licensed physician, following these steps will make the process simple and easy:

  1. Download and print the TriMix Prescription Form.
  2. Present the form to your physician (usually your family doctor or urologist).
  3. Your physician will fax the completed form to Olympia Pharmacy. Then, Olympia will ship medication directly to you.

TriMix is also available online now for those without a doctor or those who wish to get the medication without involving their doctor. Patients can complete our online telemedicine questionnaire and a member of our scheduling staff will be in contact to set up an evaluation over the phone with a licensed telemedicine physician.

Ready to get started? Buy TriMix online now and be on your way to experiencing a healthier, happier sex life!

Buy TriMix Online

TriMix’s 3 Main Ingredients: Papaverine, Phentolamine and Alprostadil

TriMix is made up of three ingredients that act symbiotically when combined together into a sterile injection. These ingredients include: Papaverine, Phentolamine and Alprostadil. These ingredients can be indicated for a number of conditions on their own, but when combined together, can have highly effective results, as it has become one of the go-to treatment options for men who do not have effective results from conventional PDE5 inhibitors.


Papaverine as a standalone medication is typically prescribed to patients with circulation problems in order to increase blood flow. As a vasodilator, papaverine relaxes and dilates blood vessels to help blood flow more easily to the heart and throughout the body. Papaverine relaxes smooth muscle within large blood vessels, especially coronary, systemic peripheral and pulmonary arteries, and is almost completely devoid of effects on the central nervous system.

The reason this ingredient is helpful for men struggling with ED is that it helps to provide improved circulation to the penis, enabling them to obtain and maintain a full erection for intercourse.


Phentolamine is a lasting, adrenergic, alpha-receptor blocking agent that works to enhance blood flow to the skin, mucosa and abdominal viscera, as well as lower blood pressure. Phentolamine works by blocking alpha receptors in the body, which can be found in the muscle that lines the walls of blood vessels. When these alpha receptors are blocked by phentolamine, muscles relax and blood vessels widen, resulting in a substantial increase in blood flow.


Alprostadil can be used to address symptoms of erectile dysfunction in men. Alprostadil, also a vasodilator, is used to relax the muscles and blood vessels in the penis to allow a steady flow of blood to the penis the user can achieve and maintain an erection. In three different studies conducted on the efficacy and safety of this ingredient used for intracavernosal treatment, it was found that alprostadil is an effective therapy with tolerable side effects.

TriMix Injection Studies

For detailed information about TriMix injections and their results, read this TriMix study conducted by the International Journal of Impotence Research below.

Introduction and Objective:

Intracavernous injection of Trimix (Tx) is indicated for patients unsuitable for prostaglandin E1 (PgE1) injection due to lack of response, pain or cost. We believe that the ideal ratio of ingredient doses in Tx is yet to be found. We postulated that increasing the doses of individual drug components in an orderly manner would convey important data on penile hemodynamic response. Such information is needed to choose an effective and less costly alternative to PgE1 with least side effects. We set out to evaluate the impact of varying the ingredient dosage on response and short-term safety of Tx compared with PgE1. We prospectively randomized 180 consecutive patients with erectile dysfunction into nine equal groups and each group received a different dose of Tx, namely phentolamine (1 mg) plus one dose of PgE1 (2.5, 5 or 10 μg) and one dose of papaverine (5, 10 or 20 mg). Each patient was injected with 20 μg PgE1 and one dose of Tx in two clinic visits 1 week apart. Following injection, duplex ultrasound of cavernous arteries and axial rigidometry were carried out. Patients ranked the quality of erection, estimated overall satisfaction and reported time to detumescence and side effects. Patients’ mean age was 50.5±11.7 y with underlying organic condition in 91.1%. We set out to evaluate, by means of an acute, prospective, randomized, single blind study, the various dose combinations of Tx versus PgE1 20 μg using both subjective and objective end points.


We think that the ideal ratio of ingredient doses in Tx is yet to be found. The effect of increasing individual drug components on penile response is not known. Such information is needed to choose an effective and less costly alternative to PgE1 with least side effects.


In spite of oral drug therapy for ED, there is a considerable number of candidates for self-injection therapy. These include patients who do not respond to or have a contraindication for PDE-5 inhibitor treatment. In addition, some patients prefer the rigidity provided by injections. In patients undergoing ICI therapy and given the option to try sildenafil, 36.2% decided to use injections most of the time or at least sporadically. The association of multiple vasoactive drugs produces a full erectile response in more than 90% of patients. In nonresponders to doses as high as 40 μg PGE1, Tx combination produced a response in 31%. The cost of the medication is another important issue where Tx has an advantage. Learn more in the study here.

Buy TriMix Now