Methylcobalamin (B12)

Methylcobalamin, also known as Vitamin B12, is an important vitamin needed for the brain, nerves, and production of red blood cells in the body. It is used to treat not only vitamin B12 deficiency, but also other conditions, such as pernicious anemia and diabetes.

 

Dosage Strength

  • Dosages depend on your age and condition. Talk with your doctor or pharmacist to see what is right for you.

 

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General Information

Methylcobalamin, also known as Vitamin B12, is an important vitamin needed for the brain, nerves, and production of red blood cells in the body. It is used to treat not only vitamin B12 deficiency, but also other conditions, such as pernicious anemia and diabetes. It also helps increase metabolic energy and improve mood regulation. Some clinical trials are also testing its use in people with dementia as well.

Methylcobalamin is made both in the body and created within a laboratory for supplemental purposes. Most vitamin B12 supplements contain cyanocobalamin, which is another form of B12. However, in order for the B12 to be utilized in the body, the liver must detoxify the cyanocobalamin and attach it to a methyl group to form methylcobalamin, the biologically active and tissue-ready form. Research shows that methylcobalamin is more efficiently used and retained in the body than cyanocobalamin. Methylcobalamin can also be found in foods, such as clams, mollusks, liver, fish, lamb, veal, beef, and dairy products. 

 

Indications

Methylcobalamin is indicated in those with vitamin B12 deficiency, pernicious anemia, diabetes, neuropathy, heart disease, circadian rhythm sleep disorders, memory loss, depression, fatigue, AIDS, inflammatory bowel disease (IBD), Lyme disease, osteoporosis, tendonitis, psychiatric disorders, Alzheimer’s disease, liver and kidney disease, and asthma. It also helps in improving concentration, maintaining fertility, anti-aging, boosting energy levels, and mood elevation.

 

Side Effects

Methylcobalamin may cause some GI effects, such as:

  • – Anorexia
  • – Diarrhea
  • – Headache
  • – Nausea
  • – Vomiting

 

Dosage

Dosages depend on your age and condition. Talk with your doctor or pharmacist to see what is right for you.

 

Contraindications

There are no contraindications for methylcobalamin. However, speak with your doctor if you:

  • – are allergic to vitamin B12
  • have a genetic condition called optic atrophy
  • have blood in your urine
  • have polycythemia
  • have an ongoing infection
  • have low iron or folate levels
  • are pregnant or plan to become pregnant
  • are breastfeeding or plan to breastfeed

 

Interactions

Some medications, supplements, or over-the-counter drugs may interact with methylcobalamin. Some include:

  • – Prilosec (omeprazole) and other proton pump inhibitors
  • – Alcohol
  • – Aminosalicylic acid
  • – Chloramphenicol
  • – Colchicine
  • – Metformin
  • – Neomycin

You should also avoid eating grapefruit or drinking grapefruit juice as well.