Methylcobalamin, also known as Vitamin B12, is an important vitamin needed for the brain, nerves, and production of red blood cells in the body. Methylcobalamin is made both in the body and created within a laboratory for supplemental purposes. Methylcobalamin can also be found in foods, such as clams, mollusks, liver, fish, lamb, veal, beef, and dairy products.
Vitamin B12 deficiency is rare in healthy individuals; it is more commonly found in the elderly and those with strict diets or gastrointestinal conditions. Prolonged B12 deficiency can impair red blood cell production, leading to anemia, along with possible gastrointestinal issues and nerve damage.
Methylcobalamin is used to treat not only vitamin B12 deficiency but also other conditions, such as pernicious anemia and diabetes. It also helps increase metabolic energy and improve mood regulation. Some clinical trials are also testing its use in people with dementia as well.
Methylcobalamin vs. Cyanocobalamin
Most vitamin B12 supplements contain cyanocobalamin, which is another form of B12 not found naturally. Cyanocobalamin is popular as it’s both a stable and cost-effective form of B12. However, in order for the B12 to be utilized in the body, the liver must convert the cyanocobalamin to a biologically active and tissue-ready form, either by converting it to adenosylcobalamin or attaching it to a methyl group to form methylcobalamin. By choosing to supplement with methylcobalamin, one can circumvent this detox process. Research shows that methylcobalamin is more efficiently used and retained in the body than cyanocobalamin.
Methylcobalamin is indicated in those with vitamin B12 deficiency, pernicious anemia, diabetes, neuropathy, heart disease, circadian rhythm sleep disorders, memory loss, depression, fatigue, AIDS, inflammatory bowel disease (IBD), Lyme disease, osteoporosis, tendonitis, psychiatric disorders, Alzheimer’s disease, liver and kidney disease, and asthma. It also helps in improving concentration, maintaining fertility, anti-aging, boosting energy levels, and mood elevation.
Methylcobalamin may cause some GI effects, such as:
- – Anorexia
- – Diarrhea
- – Headache
- – Nausea
- – Vomiting
Dosages depend on your age and condition. Talk with your doctor or pharmacist to see what is right for you.
There are no contraindications for methylcobalamin. However, speak with your doctor if you:
- – are allergic to vitamin B12
- – have a genetic condition called optic atrophy
- – have blood in your urine
- – have polycythemia
- – have an ongoing infection
- – have low iron or folate levels
- – are pregnant or plan to become pregnant
- – are breastfeeding or plan to breastfeed
Some medications, supplements, or over-the-counter drugs may interact with methylcobalamin. Some include:
- – Prilosec (omeprazole) and other proton pump inhibitors
- – Alcohol
- – Aminosalicylic acid
- – Chloramphenicol
- – Colchicine
- – Metformin
- – Neomycin
You should also avoid eating grapefruit or drinking grapefruit juice as well.
This product is available at our 503A/503B pharmacy.