How to Improve Your Hair & Skin Health With Biotin

Woman with long straight hair and freckles smiling and holding her hair against a neutral background.

When it comes to healthy hair, glowing skin and strong nails, what you put into your body matters just as much as what you put on the surface. One nutrient that often comes up in this conversation is biotin, also known as vitamin B7. Found naturally in everyday foods, biotin plays a role in turning food into energy and may also support the tissues that make up hair, skin and nails.

In this article, we’ll look at what biotin is, how it works in the body and what current research says about its role in beauty and wellness from the inside out.

What Is Biotin?

Biotin is a water-soluble B vitamin that acts as a helper molecule (coenzyme) for enzymes called carboxylases. These enzymes are essential for breaking down and using fats, proteins and carbohydrates for energy.

Because humans cannot make their own biotin, it must come from your diet. Small amounts are produced by bacteria in the gut, but most of what you need comes from a diet of foods like eggs, nuts, seeds, legumes and whole grains. A well-balanced diet generally provides 30-70 micrograms (mcg) per day, which is enough to meet daily needs[1]

Deficiency is rare, but it can occur with malnutrition, certain gastrointestinal conditions, some medications, chronic alcohol use or prolonged raw egg consumption[1]. In deficiency states, studies have linked low biotin to higher levels of inflammatory signals and disruptions in immune cell activity[1][2], underscoring its broader role in overall wellness. 

What are the Benefits of Biotin?

In people who are deficient, correcting low biotin levels can improve common symptoms such as thinning hair[3], brittle nails[4] or skin rashes[5]. Adequate biotin also supports cellular energy, which is critical for both daily function and long-term health[6]. Newer research suggests biotin may influence how cells communicate, regulate genetic activity and even support the balance of normal immune function[1][7][8].

For most healthy adults who eat a varied diet, deficiency is uncommon. While extra supplementation has not consistently been shown to enhance hair or nail growth in people without a deficiency, maintaining sufficient biotin intake is considered part of a strong nutritional foundation for overall wellness.

Find Out More About Biotin

How Biotin Benefits Hair Health

Biotin supports the metabolism of amino acids, the building blocks of proteins like keratin, which is the main structural protein in hair[3]. Therefore, adequate intake of biotin may help support healthy hair. 

Deficiency states highlight this connection most clearly. Research suggests that when biotin levels are low, people are more likely to experience hair loss, thinning and brittle texture[3]. Correcting deficiency may reverse hair loss in both humans and animal models, with regrowth occurring once biotin was reintroduced[3]

In documented deficiency or specific conditions like uncombable hair syndrome, research has suggested that supplementation may help improve symptoms[9]

Outside of these scenarios, high-quality trials showing thicker or faster-growing hair in healthy people are lacking, so results can vary.

Woman with curly hair and freckles smiling while gently touching her cheek in front of a mirror.

How Biotin Benefits Skin Health

Your skin acts as a protective barrier against irritants, pathogens and environmental stressors, and biotin contributes to several of the processes that keep that barrier strong. Biotin-dependent enzymes are involved in fatty acid synthesis and energy metabolism, both of which are important for maintaining skin cell integrity and the lipid layer that locks in moisture[3]. When biotin is low, early signs can include dry, irritated or scaly rashes, often around the mouth, eyes or nose[5].

Research also suggests biotin may play a role in broader skin health. It supports the renewal of skin cells, contributes to keratin production and helps preserve the lipid barrier that helps reduce the risk of dehydration[3]

Because nail, skin and hair tissues share keratin-related pathways, biotin has also been studied for nail health. Supplementation has been linked with stronger, thicker nails in people with brittle nail conditions[3][4]. However, evidence in otherwise healthy individuals remains limited, so most people will meet their needs through diet rather than supplements.

How to Take Biotin

Most people get enough biotin naturally through a balanced diet. Some of the most biotin-rich foods include organ meats like liver, fatty fish such as salmon, pork, eggs, sunflower seeds, sweet potatoes and nuts[10]

In some cases, your provider may suggest supplementation. Biotin supplements are available in oral forms and may also be compounded for injection. Because dosing can vary depending on your health status, it’s important to follow the guidance of a licensed healthcare provider rather than starting supplementation on your own.

Things to Consider Before Taking Biotin

Biotin is generally well tolerated, and even very high intakes (10-200 mg/day) have not shown toxicity in humans[10]. That said, there are a few important notes:

  • Lab test interference: High doses of biotin can affect certain lab results (such as thyroid hormone or vitamin D tests), sometimes leading to false positives or negatives[10]. Providers may have you pause supplementation before specific blood tests.
  • Groups with Higher Needs or Risks[10]:
    • Pregnancy & Lactation: Marginal biotin deficiency occurs in up to one-third of pregnant women and is also seen in lactating women, even with normal intake.
    • Smokers: May metabolize biotin more rapidly.
    • Chronic Alcohol Use: Associated with reduced absorption; about 15% of individuals with alcoholism have low plasma biotin.
    • Anticonvulsant Therapy: Drugs such as carbamazepine, phenytoin, and phenobarbital increase biotin breakdown and decrease absorption, often leading to lower serum levels.

Explore How Biotin May Support Your Wellness Goals

Biotin is more than just a “beauty vitamin” — it plays a role in energy metabolism while also potentially contributing to the hair, skin and nail health. For most people, a balanced diet provides enough biotin, but some individuals may benefit from supplementation under the guidance of a healthcare provider.

By keeping your nutrition on track and understanding how nutrients like biotin fit into overall wellness, you can support both how you feel and how you look, from the inside out.

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Sources

  1. Lis K. Biotin Supplementation—The Cause of Hypersensitivity and Significant Interference in Allergy Diagnostics. Nutrients. 2025 Jan;17(15):2423. 
  2. Agrawal S, Agrawal A, Said HM. Biotin deficiency enhances the inflammatory response of human dendritic cells. Am J Physiol Cell Physiol. 2016 Sep 1;311(3):C386-91. doi: 10.1152/ajpcell.00141.2016. Epub 2016 Jul 13. PMID: 27413170; PMCID: PMC5129763.
  3. Kannan S, Balakrishnan J, Nagarajan P. Vitamin B7 (Biotin) and its role in hair, skin and nail health. In: Hydrophilic Vitamins in Health and Disease. Springer; 2024. p. 233-52. 
  4. Lipner SR, Scher RK. Biotin for the treatment of nail disease: what is the evidence? Journal of Dermatological Treatment. 2018 May 19;29(4):411-4. 
  5. Folate I of M (US) SC on the SE of DRI and its P on, Vitamins OB, Choline A. Biotin. In: Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline [Internet]. National Academies Press (US); 1998 [cited 2025 Sept 19]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK114297/
  6. Said HM. Biotin: biochemical, physiological and clinical aspects. Subcell Biochem. 2012;56:1-19. 
  7. Zempleni J. Uptake, localization, and noncarboxylase roles of biotin. Annu Rev Nutr. 2005;25:175-96. 
  8. Agrawal S, Agrawal A, Said HM. Biotin deficiency enhances the inflammatory response of human dendritic cells. Am J Physiol Cell Physiol. 2016 Sept 1;311(3):C386-91. 
  9. (PDF) Uncombable hair improved by biotin. ResearchGate [Internet]. [cited 2025 Sept 19]; Available from: https://www.researchgate.net/publication/368342911_Uncombable_hair_improved_by_biotin
  10. Office of Dietary Supplements – Biotin [Internet]. [cited 2025 Sept 19]. Available from: https://ods.od.nih.gov/factsheets/Biotin-HealthProfessional/

ED Care Options | Oral Medications & Trimix Injectable Therapy

The Need for More ED Care Options

Erectile dysfunction (ED) affects a significant portion of the male population, and while oral medications like sildenafil, tadalafil, and vardenafil are commonly used, they may not be the best option for every patient. 

The First Line of Defense

Oral ED options (known as PDE-5 inhibitors) include medications such as sildenafil, tadalafil, and vardenafil. They are often the first care plan recommended to patients because of their ease of use.

At Olympia, we compound oral medications with the following ingredients:

  • Sildenafil (Generic Viagra ®)
  • Tadalafil (Generic Cialis ®)
  • Vardenafil (Generic Levitra ®)

In some cases where these individual ingredients may not appear to be the right strength for certain patients’ needs, combo medications may be prescribed. Olympia offers combination oral tablets such as:

  • Sildenafil / Tadalafil
  • Sildenafil / Vardenafil
  • Tadalafil / Apomorphine / Methylcobalamin B12
  • Tadalafil / Vardenafil
  • Vardenafil / Papaverine
  • Tadalafil / Oxytocin
…and more!

Even with the introduction of combo tablets, some patients may not be good candidates for oral tablets as a whole. Whether it’s due to contraindications or the medications do not respond as expected, this prompts a need for additional care options.

When to Consider Injectable Therapy

Three vials of compounded Trimix injection vials stand in a line. From left to right, a Bimix vial with a gold cap and label, a Trimix vial with a blue-striped cap and blue label, and a Quadmix vial with a blue cap and blue label.

For patients who do not respond to or cannot take oral medications, injectable therapy may be considered. There is a variety of terms in which this type of therapy is referred to, including:

  • ED shot 
  • Penile shot 
  • Penile injection 
  • Intracavernosal injection therapy

No matter the terminology used, they all mean the same thing. This method of care is often seen as a viable pathway for patients dealing with more serious cases of erectile dysfunction.

When it comes to injectable therapy, one of the most common options prescribed to patients is known as Trimix Injection.

What Is Trimix?

Trimix is a compounded injectable medication that typically combines three active ingredients: alprostadil, papaverine, and phentolamine. It is administered via injection into the corpora cavernosa of the penis, also known as the penile tissue, under provider guidance. As a combination drug, it is compounded in a sterile environment by compounding pharmacies like Olympia.

Comparison Chart: Oral vs. Injectable ED Therapies

Aspect Oral PDE-5 Inhibitors (Sildenafil, Tadalafil, Vardenafil) Injectable Therapy (e.g. Trimix)
Concentration and route of administration Rapidly dissolving tablets administered orally Injections administered intracavernosally
Onset Typically 30-60 minutes Typically within 5-20 minutes
Customization Fixed doses available Can be titrated per patient
Use Case First-line care Considered if patient has poor response to oral medications
Monitoring Minimal Follow-up and monitoring recommended

Safety and Handling Considerations

Providers should ensure proper patient education on injection technique, sterile handling, and dosing. Monitoring for adverse events and following up with patients is recommended.

Role of L-Arginine as a Supplement

In some cases, clinics may recommend dietary supplements such as L-Arginine. This amino acid, when found in the body, supports nitric oxide production, which plays a role in vascular health. As with any additions to a patient’s care regimen, providers should review patient health profiles before suggesting any supplement to ensure there is a fit.

Practical Considerations for Clinics

Clinics offering injectable ED therapy should:

  • Partner with an FDA-registered facility. 
  • Provide training on administration and handling. 
  • Establish protocols for dosing and follow-up. 
  • Offer educational resources for patients.

Be advised that compounded products are not approved by the FDA, nor are they evaluated by the FDA for safety, efficacy, or quality. This article was written for informational purposes, and is not intended to replace or substitute for medical advice. Always consult with a medical professional before beginning any medical regimen.

 

For clinics and providers looking to expand their ED care options, injectable therapy such as Trimix can be part of a comprehensive solution for patients who need alternatives to oral medications.

Interested in learning more about how your clinic can offer injectable ED therapy? Contact us to speak with a representative about protocols, patient education, and support resources.

How To Self-Administer Subcutaneous & Intramuscular Injections

A woman administering a subcutaneous injection into her abdomen using a syringe.

Wellness and weight-loss injections are becoming increasingly common, especially with the rise of GLP-1 therapies and other compounded formulations that support energy, metabolism and overall wellness. While self-injection can feel intimidating at first, the process becomes manageable — and even routine — with the right preparation, technique and provider guidance.

In this guide, we’ll walk you through how to carefully self-administer subcutaneous (SubQ) and intramuscular (IM) injections, explain when each method is typically used, and share practical tips to help you feel confident and informed at every step.

Understanding Injection Types

When it comes to wellness and weight management therapies, not all injections work the same way. Some are designed for slower, sustained absorption, while others deliver results more quickly. Understanding the difference between SubQ and IM injections can help you feel more confident when discussing treatment options with your provider.

Subcutaneous (SubQ) Injections

SubQ injections are administered just beneath the skin into the fatty tissue layer. Because they use smaller, finer needles and deliver medication gradually, they’re typically less uncomfortable and better suited for formulations that benefit from slower absorption. Many of Olympia’s wellness and weight-management therapies, including Cyanocobalamin (B12), Liraglutide, Sermorelin and NAD+, are commonly administered this way.

Intramuscular (IM) Injections

IM injections deliver medication deeper into the muscle, where it can be absorbed into the bloodstream more quickly. These injections often use slightly longer needles and are ideal for therapies where faster uptake is beneficial. L-Carnitine and some MICC formulations are often administered intramuscularly, especially when supporting fat metabolism or boosting energy.

Have Questions? We’re Here to Help

Preparing for a Proper Self-Injection

Taking a few minutes to prepare before giving yourself an injection can make the process smoother and less stressful. Focus on creating a clean, organized environment and reviewing your provider’s instructions before you begin.

1. Choose a Clean, Quiet Space

Choose a flat, well-lit surface where you can lay out your supplies. Make sure the area is clean and free from distractions. Having everything within reach helps you stay focused and avoid mistakes.

2. Wash and Sanitize Your Hands

Wash your hands thoroughly with soap and warm water for at least 20 seconds, then dry them completely. If soap and water aren’t available, use an alcohol-based hand sanitizer instead.

3. Gather Your Supplies

Before starting, make sure you have all the items you’ll need within reach, such as:

  • Medication vial(s)
  • Syringe and needle
  • Alcohol swabs
  • Sharps disposal container
  • Gauze or cotton pads

Having all your supplies ready ahead of time helps the process go smoothly.

4. Review Provider Instructions

Before you begin, carefully review the instructions given by your licensed provider. This ensures you understand the correct medication, dosage and administration method for your medication.

5. Create a Focused Environment

Keep pets, children and distractions away from your injection area. Make sure you’re comfortable and can focus entirely on the steps ahead.

Close-up of a woman preparing to give a subcutaneous injection in her lower abdomen.

How to Self-Inject Subcutaneously

SubQ injections deliver medication into the fatty layer just beneath the skin. Following these steps can help make the process consistent and more comfortable.

1. Measure Your Dose

Always begin by reviewing the instructions provided by your licensed provider. Your prescription will indicate the exact amount of medication to use, often listed in milliliters (mL) or units. When using an insulin syringe, remember to measure the dosage using the top of the plunger stopper for accuracy.

2. Choose an Injection Site

SubQ injections are typically given in areas with more fatty tissue. Common sites include:

  • Upper arm (deltoid): Backside of the arm, halfway between the elbow and shoulder.
  • Belly (abdomen): Below the ribs and above the hip bones, at least 2 inches away from the belly button.
  • Thigh: Upper portion of the thigh, between the front and outer areas.

3. Prepare Your Medication

  • Wash your hands thoroughly with soap and warm water.
  • If your medication is stored in the refrigerator, allow the vial to sit at room temperature for about 10 minutes.
  • Remove the protective metal foil seal by lifting the perforated ring and peeling it away.
  • Wipe the rubber stopper on the vial with an alcohol swab and allow it to dry completely.

4. Load the Syringe

  • Hold the vial upright and puncture the rubber stopper with the needle.
  • Turn the vial upside down and slowly draw up your prescribed dose into the syringe.
  • Use the top edge of the plunger stopper to measure your dose accurately (e.g., 10 units = 0.1 mL).
  • Tap the syringe gently to bring any air bubbles to the top, then push out the excess air before injecting.

5. Sanitize and Pinch the Skin

  • Sanitize your chosen injection site with a fresh alcohol swab and let it dry.
  • Using your non-dominant hand, gently pinch 1-2 inches of skin to create a stable surface.

6. Insert the Needle

  • Hold the syringe in your dominant hand and position the needle at a 90° angle.
  • Insert the needle using a smooth, steady motion until it’s fully under the skin.
  • Push down on the plunger slowly and evenly until the full dose is delivered.
  • Remove the needle at the same angle, then apply gentle pressure to the site with a clean cotton pad or gauze for a few seconds.

7. Remove and Dispose

  • Dispose of the used needle and syringe immediately in an FDA-cleared sharps container or another designated disposal container.
  • Apply light pressure with gauze or a clean cotton pad if any bleeding occurs.
  • Avoid rubbing the area, but you can lightly massage it if your provider recommends it.

For a clear visual guide, watch our YouTube tutorial here.

YouTube video

A man administers an intramuscular injection into his thigh using a syringe.

How to Self-Inject Intramuscularly

IM injections deliver medication directly into the muscle, where it can be absorbed more quickly than subcutaneous injections. With the right preparation and technique, IM injections can be performed at home under the guidance of your licensed provider.

1. Measure Your Dose

Start by reviewing the dosage instructions provided by your licensed provider. Similar to SubQ injections, your prescription may list the amount in mL, units or both. Always confirm the exact dose before preparing your injection.

2. Choose an Injection Site

Intramuscular injections are typically administered in one of three locations:

  • Upper arm (deltoid): Outer, rounded part of the upper arm, about halfway between the shoulder and elbow.
  • Thigh: Upper outer portion of the thigh, between the front and side of the leg.
  • Gluteus maximus: Upper outer quadrant of the buttock, away from major nerves and blood vessels.

3. Prepare Your Medication

  • Wash your hands thoroughly with soap and warm water.
  • Remove the protective foil seal from the vial by lifting the perforated ring and peeling it away.
  • Clean the rubber stopper with an alcohol swab and let it dry completely.

4. Load the Syringe

  • Hold the vial upright and puncture the rubber stopper with the needle.
  • Turn the vial upside down and slowly draw up your prescribed dose into the syringe.
  • Use the top edge of the plunger stopper to measure the dose accurately.
  • Tap the syringe gently to bring any air bubbles to the top, then push out the excess air before injecting.

5. Sanitize the Injection Site

  • Clean the chosen area with a fresh alcohol swab and let it dry completely.
  • Avoid touching the sanitized area after cleaning to reduce the risk of introducing bacteria.

6. Insert the Needle

  • Hold the syringe in your dominant hand and position the needle at a 90° angle.
  • Insert the needle using a smooth, dart-like motion until it reaches the muscle.
  • Slowly depress the plunger to deliver the medication at a steady pace — about 1 ml every 10 seconds is a good guideline for minimizing discomfort.
  • Remove the needle at the same angle it entered and apply gentle pressure to the site with gauze or a cotton pad.

7. Remove and Dispose

  • Dispose of the used needle and syringe immediately in an FDA-cleared sharps container or another designated disposal container.
  • Apply light pressure with gauze if there’s minor bleeding.
  • Avoid rubbing the area, but you can lightly massage it if your provider recommends it.

For a clear visual guide, watch our YouTube tutorial here.

YouTube video

 

Illustration comparing intramuscular and subcutaneous injection techniques with needle angles and tissue layers.

Best Practices for Self-Injections

Following proper injection techniques helps reduce irritation, reduce the risk of infection and ensure consistent medication absorption. Keep these tips in mind every time you prepare and administer an injection:

  • Rotate injection sites: Switch up your injection spots to avoid irritation, bruising and scar tissue. Rotating sites also helps maintain steady absorption of your medication.
  • Use a new needle and syringe every time: Never reuse equipment. Fresh, sterile supplies reduce the risk of infection and make injections more comfortable.
  • Sanitize before injecting: Wash your hands thoroughly and clean the injection site with an alcohol swab before every injection.
  • Watch for warning signs: Contact your licensed provider if you notice persistent redness, swelling, bruising, warmth, pus or other signs of infection, as well as any unexpected side effects.
  • Dispose of supplies properly: Place used needles and syringes in an FDA-cleared sharps container or another designated disposal container. Learn more about proper disposal

Frequently Asked Questions About Self-Administering Injections

1. What’s the difference between SubQ and IM injections?

The main difference is where the medication is delivered:

  • SubQ injections go just beneath the skin into the fatty tissue layer. They typically use smaller, finer needles and are designed for slower, sustained absorption. 
  • IM injections go deeper into the muscle, allowing the medication to be absorbed more quickly into the bloodstream. 

2. Where is the best place to inject SubQ?

The best areas for SubQ injections are places on the body with a soft layer of fatty tissue just beneath the skin. These spots tend to be less sensitive and make it easier for the medication to absorb gradually. Many people find the upper arm, abdomen and thigh to be the most comfortable and accessible. To reduce irritation and minimize the risk of scar tissue, it’s best to rotate between injection sites rather than using the same spot every time.

3. Do self-injections hurt?

Most people experience only mild discomfort during self-injections, especially with SubQ injections that use smaller, finer needles. Intramuscular injections may feel slightly more noticeable since the needle goes deeper into the muscle, but using proper technique and following your provider’s instructions can make the process more comfortable.

4. How can I avoid bruising from injections?

Bruising is common and usually harmless, but you can reduce the risk by:

  • Rotating injection sites to avoid overusing the same area.
  • Allowing alcohol from the prep swab to fully dry before injecting.
  • Using a smooth, steady motion when inserting the needle.
  • Applying gentle pressure and not rubbing the area after removing the needle.

If bruising persists or worsens, check in with your licensed provider.

5. How do I dispose of needles properly?

Always place used needles, syringes and related supplies in an FDA-cleared sharps container or another designated disposal container immediately after use. Never throw loose needles into household trash.

Learn more about how to dispose of used needles and syringes properly.

6. Can I give myself an IM injection?

Yes, many people self-administer intramuscular injections at home, but it’s important to:

  • Follow your provider’s instructions closely.
  • Choose an appropriate injection site, such as the deltoid, thigh or gluteus maximus.
  • Practice proper preparation and sanitation techniques.

If you ever feel unsure, ask your licensed provider to demonstrate the correct technique before attempting an IM injection on your own.

Discover Olympia’s Provider-Guided Injection Therapies

Learning to self-administer injections can feel overwhelming at first, but with practice, proper preparation and provider guidance, it quickly becomes a manageable part of your wellness routine. Whether your therapy involves subcutaneous or intramuscular injections, following the right techniques and best practices can make all the difference in your comfort and confidence.

Olympia Pharmacy is committed to supporting your health journey by providing high-quality compounded formulations and educational resources that help you to feel informed and in control. From weight-loss therapies to wellness blends, our provider-guided medications are designed to fit into your lifestyle.

Ready to learn more about Olympia’s physician-guided injection therapies?

Connect With Our Team

What the B Vitamins in Olympia Vita-Complex Do & Why They Work Together

What the B Vitamins in Olympia Vita-Complex Do & Why They Work Together

Vita-Complex & Why Olympia Blended These B Vitamins

Vita-Complex is a B-complex vitamin blend designed for intramuscular (IM) or intravenous (IV) use. It includes key B vitamins such as B1 (thiamine), B2 (riboflavin-5-phosphate), B3 (niacinamide), B6 (pyridoxine), and B5 (dexpanthenol). Vita Complex is utilized in regimens that emphasize energy production and skin health. 

B vitamins Vita Complex

What Each B Vitamin Does (Individually + Together)

Below is a breakdown of what some of the main B vitamins in Vita Complex do on their own, and how they collaborate as a blend.

Vitamin Individual Role How It Contributes in the Blend
B1 (Thiamine) Helps convert food (carbs) into energy. Supports nerve cell function.  As part of Vita Complex, supports initial steps of metabolism so other B vitamins have fuel to work.
B2 (Riboflavin-5-phosphate) Converts food into energy, aids in supporting brain and heart health Essential to the metabolism of B3 and B6.
B3 (Niacinamide) Helps metabolism, cellular signaling, DNA repair, skin health.  Works with B1 and B2 to help release energy; skin effects are often noticed when used with B complex.
B5 (Dexpanthenol) Plays a part in supporting skin and hair health, as well as breaking down fatty acids. Supports the metabolic process, converting food into energy.
B6 (Pyridoxine) Involved in protein metabolism, neurotransmitter formation, red blood cell production. Frequently converted to its active form (PLP) in the body.  Supports mood and brain chemistry; helps with amino acid metabolism in the overall blend.

 

Pyridoxine (Vitamin B6) on Its Own

Pyridoxine, a form of Vitamin B6, plays a unique role when administered by itself. Among other functions, it’s critical for amino acid metabolism, production of neurotransmitters (brain chemicals), and red blood cell health. Some people receive B6 injections to target specific needs like mild nervous system issues or to support diet-related gaps.

Olympia offers compounded pyridoxine as an injectable medication.

Other B Vitamins

While Vita Complex encompasses a wide range of B vitamins, it doesn’t include all of them. Luckily, Olympia carries other B vitamins on their own. B12 by itself, for example, is a viable option that’s often used when a patient’s natural B12 levels are low or specific conditions exist. Olympia compounds three variants of B12, each with their own benefits:

  • Methylcobalamin: The natural version of Vitamin B12. When compounded into injectable form, it is often promoted for better neural uptake and methylation pathways.
  • Cyanocobalamin: A common, stable variant of B12 found in many supplements.
  • Hydroxocobalamin: This form, typically used in injections, tends to have a longer half-life in body tissues.

Do Kits Always Carry at Least One B Vitamin?

Almost. In nearly every one of our IV kits and premixes, B-vitamins are present. The only exception is the Snow Bright IV Kit, which is made up of ascorbic acid (Vitamin C), Alpha Lipoic Acid, and Glutathione. B vitamins are available from vials such as Vita Complex, Pyridoxine, Methylcobalamin, or Myers’ Cocktail.

The reason B vitamins are so prominent across our IV Kits and Premixes is because they are foundational in metabolic processes, converting food into usable energy, supporting skin, blood cell formation, and maintaining nervous system function. (Olympia IV Nutritional Therapy Premixes overview) Olympia Pharmaceuticals+1

 

The Vita Complex Formula

When you combine B1, B2, B3, B6, and B5, you get overlapping and complementary benefits:

  • The “energy chain” works better when all parts are present (e.g., B1 helps start, B2 and B3 continue, B6 helps process amino acids, B12 helps with tissues like red blood cells).
  • Skin health often improves when multiple B vitamins are present: for example, B3 helps with skin texture, B6 supports cell turnover.
  • Brain and mood pathways rely heavily on B6 (for neurotransmitters and methylation).
  • Because these are water-soluble vitamins, the body uses what it needs and excess is typically excreted , so regular administration via intramuscular/intravenous injection (as with Vita Complex) helps maintain consistent levels.

 

Considerations

It’s important to approach new regimens and care options with knowledge of potential side effects and contraindications. Be sure to discuss with a medical practitioner before beginning any kind of new medication, including the Olympia Vita-Complex.

When given Olympia Vita-Complex, there is a chance that you may encounter side effects such as nausea, vomiting, diarrhea, dizziness, headaches, and a rash at the injection site. In higher doses, you may encounter peripheral neuropathy (a tingling/numb sensation) and/or ataxia (loss of muscle control).

When it comes to contraindications, it is advised that you do not take Olympia Vita-Complex if you suffer from renal impairment.

This article is for informational purposes and not intended to replace medical advice. Always consult with your medical provider to determine if a medication is a right fit for you.

5 Nutrients to Know This Cold and Flu Season

With the cold and flu season on the rise, many people are looking for ways to provide extra support to their body. From boosting nutrient intake to adding targeted injections, supplements, or self administration, there are a plethora of ways clinics can show up for their patients around this time of year. Here are five you’ll want to be on top of.

1. Ascorbic Acid (Vitamin C)

Ascorbic Acid, also known as Vitamin C, is one of the most popular nutrients for immune support. Found in fruits and vegetables like oranges, strawberries and bell peppers, it plays an essential role in helping white blood cells function properly and contributes to collagen production, which is important for skin and tissue health. During cold and flu season, ascorbic acid is often included in IV blends and injections for those looking to increase their intake quickly.

Learn more about Ascorbic Acid from Olympia Pharmacy

2. Tri-Immune Boost

Tri Immune bottle

Tri-Immune Boost is a specialty injection that combines three ingredients in one: ascorbic acid, zinc, and glutathione. Together, these nutrients are formulated into a unique blend and offered in clinics as a way to support immune health and overall wellness, especially during high-exposure seasons like fall and winter.

Tri-Immune Boost is injected via intravenous OR intramuscular route, making it a great choice for people traveling and in need of bodily support.

See Olympia Pharmacy’s Tri-Immune Boost

3. Zinc

zinc sulfate

Zinc is a trace mineral that supports normal immune system function. It helps immune cells communicate and is often spotlighted during cold and flu season because of its role in recovery and repair. Many wellness protocols include zinc lozenges, oral supplements, or injections as part of an immune-focused plan. Olympia offers an injectable form of zinc sulfate, both on its own and as part of our Immunity IV Kit, that’s employed in a variety of IV regimens for wellness. Zinc Sulfate is administered via intravenous route only.

Explore Zinc Sulfate at Olympia Pharmacy

4. Glutathione

Two vials of glutathione 200 mg/ml from Olympia Pharmaceuticals.

Often called the “master antioxidant,” glutathione plays an important role in detoxification and cellular defense. Because it can aid in neutralizing oxidative stress, many clinics offer glutathione as an injection, or supplementing IV drips with the antioxidant during cold and flu season. Clients often seek it out to feel refreshed or to support overall wellness during times of stress.

Check out Olympia’s Glutathione

5. Vitamin D3

A 30ml amber vial of medication. The vial has a black cap and label, which reads "Olympia Vitamin D3 - 50,000 IU/mL Injection. 1.25mg/mL."

Vitamin D3, also known as the “sunshine vitamin,” plays an important role in numerous functions of our body. Low vitamin D levels are especially prevalent during the winter months, when daylight is shorter and people spend more time indoors. Many people choose to supplement with Vitamin D3 to support immune function and bone health, as well as replenishing levels of Vitamin D in the body.

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Final Thoughts

Cold and flu season is a great time to review your wellness strategy. From tried-and-true nutrients like Ascorbic Acid and Zinc to blends like Tri-Immune Boost, there are a wide range of options available for clinics to support their patients.

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IV Clinics vs. Hydration Packets: Choosing the Right Solution for Your Needs

A woman wearing workout attire and wireless earbuds drinks water from a bottle while standing outdoors at sunrise.

Hydration and wellness are gaining more attention as people prioritize staying healthy and energized. Whether it’s for muscle recovery or overall health, more people are turning to electrolyte supplements and IV therapy as part of their routines. This guide explores the differences between hydration packets and IV therapy, helping you choose the option that fits your lifestyle and hydration needs.

How Electrolyte Powders Work

When it comes to staying hydrated, electrolyte powders are a simple yet powerful supplement. These convenient hydration solutions are packed with key minerals like sodium, potassium and magnesium that your body relies on to function at its best.

What Are Electrolyte Powders?

Electrolyte powders are specially formulated to replenish essential minerals like sodium, potassium and magnesium. Your body depends on these elements for hydration, muscle function and overall energy. When you sweat, are exposed to heat or experience mild dehydration, these minerals are lost, which can leave you feeling fatigued, dizzy or even impact your performance.

What makes electrolyte powders stand out is their simplicity. With just a quick mix into water, electrolyte powders can make it easier to restore this balance. Unlike many traditional sports drinks, electrolyte powders may offer these benefits:

  • Fewer calories and less sugar: Instead of loading up on unnecessary sugars, they’re designed to deliver hydration and nutrients without the extra calories.
  • Portable and easy to use: Compact packets fit seamlessly into your routine, from gym sessions to travel or busy, on-the-go schedules.
  • Quicker hydration: Specially formulated for faster absorption, they help your body recover and rehydrate when you need it most.

When To Use Electrolyte Powders

Electrolyte powders make it easy to stay hydrated throughout your day:

  • Moderate to intense exercise: Replenish lost electrolytes after physical activity to boost recovery and performance.
  • Illness recovery: Help restore hydration during illness, particularly when dehydration is a concern.
  • Daily activities: Stay balanced and energized during heat exposure, busy routines or travel.

How IV Therapy Works

IV therapy is a medical treatment designed to deliver fluids, electrolytes, vitamins and other nutrients directly into the bloodstream. This method bypasses the digestive system, allowing for immediate absorption and faster results.

What Is IV Therapy?

IV therapy involves inserting an intravenous line (small tube) into a vein, typically in the arm, to administer hydration solutions designed for your specific needs. These solutions can include:

  • Electrolytes: Maintain hydration, regulate nerve and muscle function and balance pH levels in the body.
  • Vitamins and Minerals: Provide essential nutrients that support immunity, enhance energy levels and promote overall health and recovery.
  • Medications: Formulated to align with individual health concerns, such as reducing migraine severity, replenishing nutrient deficiencies or helping to manage chronic conditions.

When to Use IV Therapy

IV therapy is most beneficial when rapid hydration or nutrient delivery is needed. Common use cases include:

  • Immune Support: Strengthen your body’s natural defenses with key nutrients, ideal for supporting recovery during cold and flu season or after an illness.
  • Energy Boost: Tackle fatigue and regain mental clarity with a fast infusion of essential nutrients, making it easier to handle demanding workloads or high-pressure schedules.
  • Physical Recovery: Facilitate faster healing and reduced soreness through hydration and nutrient delivery, designed to aid post-exercise recovery or injury rehabilitation.

Deciding Which Option Works for You

When to Choose Hydration Packets

Designed for everyday use, electrolyte powders are a simple way to help maintain electrolyte balance when mild to moderate dehydration occurs. Unlike IV drips, which require appointments and professional administration, electrolyte powders are easily accessible without the need for needles or medical supervision. They work gradually through the digestive system. This makes them ideal for:

  • Busy individuals needing portable solutions.
  • Budget-conscious hydration options.
  • Everyday situations like workouts, travel or mild dehydration.

When to Opt for IV Therapy

IV therapy is the better choice for situations requiring rapid hydration. Administered directly into the bloodstream, it may deliver faster results and can be formulated for specific health goals. It’s especially beneficial for:

  • Recovering from jet lag, illness or intense physical activity.
  • Addressing severe dehydration or nutrient deficiencies.
  • Finding solutions that complement a provider’s guidance.

Introducing Olympia Pharmacy’s Electrolyte Powders

We’ve developed our electrolyte powders with your health, convenience and wellness in mind, offering an innovative approach to hydration that fits into your lifestyle.

Our electrolyte powders are:

  • Sugar-free: Following modern wellness trends, these powders are free from unnecessary sugars, focusing instead on delivering hydration and key nutrients without the extra sugars.
  • Portable and flexible: Designed for life on the go, their compact packaging allows you to stay hydrated anywhere.
  • Crafted with trusted quality: Backed by Olympia Pharmacy’s reputation for excellence, these powders are held to the highest standards of quality.

Olympia Pharmacy GO drink mix packets in three flavors — pink lemonade, orange and strawberry — designed to support hydration and immunity.

Olympia Pharmacy: Your Partner in Hydration

Electrolyte powders and IV therapy offer practical ways to support your hydration and wellness. At Olympia Pharmacy, we’re committed to providing innovative solutions that align with your unique needs and lifestyle.

Explore our convenient electrolyte powders or learn about our IV therapy options for a rapid approach to replenishment and recovery. Discover how Olympia Pharmacy can help you achieve your wellness goals with confidence today.

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Do Lipotropics Injections Work? Your Questions, Answered

If your team fields questions about “fat-burning shots,” you’re not alone. Many clinics offer MIC (methionine, inositol, choline) blends with B-vitamins, sometimes with L-carnitine, as part of structured weight-management programs. The notes below cover common questions without making outcome promises.

What is a lipotropic B12 injection?

Lipotropics” are nutrients involved in hepatic lipid handling and methyl-group transfer (for example, choline and methionine). B12 supports hematologic and neurologic functions, and L-carnitine transports long-chain fatty acids into mitochondria. Clinics often combine these in an IM injection as one component of a broader Weight Management plan.

Olympia examples (formulations may differ by product):

Do lipotropic injections “work”?

These injections are commonly used alongside nutrition, activity, and follow-up, not as a standalone pathway. Mechanistically, choline and methionine relate to hepatic fat transport and one-carbon metabolism; carnitine supports fatty-acid transport. If your clinic offers these services, set expectations around the full program (coaching, energy balance, and adherence) rather than the injection alone.

How long until patients notice anything?

Timing varies by individual and program structure. Many clinics schedule weekly IM visits for several weeks and reassess based on logs (nutrition, physical activity, sleep) and patient feedback. Keep documentation tight so your team can adjust cadence and education as needed. (For general B12 background, see the Mayo Clinic explainer.)

How much weight can someone lose with lipotropic injections?

There isn’t a standard number attributable to the injection itself. Any change you observe typically reflects the combined program: caloric intake, protein adequacy, resistance training, and consistent follow-up. If a patient is asking about GLP-1/GIP medicines, direct them to a conversation with their prescriber and share neutral background reading on those medicines from peer-reviewed journals.

Do lipotropic injections expire?

Yes. Compounded sterile preparations carry a beyond-use date (BUD) on the label. The BUD is the date or time after which the preparation should not be used. Ensure staff check and document BUDs at each administration and follow your SOPs.

Do lipotropics need to be refrigerated?

Ultimately, this will vary from product to product. Always follow the instructions as displayed on the product label:

  • Lipo-Mino-Mix-C: Store under refrigeration (2° to 8°C/36° to 46°F).
  • Lipo-Mino-Mix and Lipo-Stat-Plus: Store at a controlled room temperature (20° to 25°C/68° to 77°F).

If You’re Looking For “Do Lipotropic Injections Work Reddit”?

Online forums contain personal reports that can vary widely, and should not substitute medical advice from your provider. Use your clinic’s intake, logs, and follow-ups to anchor conversations, and offer patients neutral educational links if they want background on individual nutrients.

Where do lipotropics fit relative to GLP-1/GIP medicines?

There is extensive published research on GLP-1/GIP medicines in weight-management settings. If a patient is exploring those medicines, keep the discussion with a licensed prescriber who knows their history. For general context, see peer-reviewed articles in major journals (reading list below).

How clinics can incorporate lipotropics

  1. Set expectations during intake: Position injections as program components; align goals to nutrition targets, activity plans, and follow-ups.
  2. Choose a formulation:
    • Start with Lipo-Mino-Mix or Lipo-Stat-Plus for MIC/B-complex combinations.
    • Consider Lipo-Mino-Mix-C if your protocol includes a carnitine-containing option; align storage workflows accordingly.
  3. Decide visit cadence: Weekly IM visits are common; reassess after several weeks using objective logs and patient-reported feedback.
  4. Document consistently: Track weight, waist, protein intake, resistance-training minutes, and sleep.
  5. Educate with neutral sources: Provide patients with plain-language resources on choline, carnitine, and B12.

Closing Thoughts

Keep in mind that this article was written for informational purposes only, and is not intended to substitute or replace medical advice from your provider. Always consult with a medical professional before beginning any form of medication.

3 Weight Loss Injections and Tablets You Might Not Know About

Close-up of a person in a blue shirt and jeans administering a subcutaneous injection into their abdomen using a syringe.

Weight loss is rarely a one-size-fits-all process. Even with the right balance of diet and exercise, many people find themselves hitting plateaus or struggling with persistent cravings or inconsistent results. When that happens, some explore medical options, and injections have become a leading choice in recent years. While some weight-loss injections have captured the spotlight in recent years, they’re not the only options available.

There are other therapies that, under the guidance of a licensed provider, may help you lose weight. In this blog, we’ll explore three such options: naltrexone, sermorelin and liraglutide. Let’s take a closer look at what they are, how they work and when they might fit into a comprehensive weight management plan.

Naltrexone

Naltrexone is an opioid receptor blocker that has been studied for its effects on eating behavior. It may influence the brain’s reward pathways, which are tied to cravings for rich, indulgent foods[1], like sweets, fried snacks or fast food. Research suggests it can make food feel less rewarding for some people, which may help reduce “reward-driven” eating patterns[2]. However, it does not consistently lower overall craving intensity, and its effects can vary between individuals.

This suggests naltrexone may be more relevant for people whose eating habits are strongly influenced by the pleasure of eating, rather than by physiological hunger cues. While it is not considered a stand-alone treatment for weight loss, naltrexone may be prescribed in combination with other therapies as part of a broader weight management plan overseen by a licensed provider.

Typical Dosing Schedule

Naltrexone is commonly prescribed as a once-daily oral tablet. Your exact dosage and schedule will depend on your provider’s guidance and your specific needs.

Side Effects

As with any prescription medication, there is the potential for side effects. Commonly reported ones may include[3]:

  • Nausea, vomiting or loss of appetite
  • Joint or muscle pain
  • Headache, dizziness or drowsiness
  • Trouble sleeping
  • Cold or allergy-like symptoms (stuffy nose, sore throat)

More serious side effects can occur, such as signs of liver problems, allergic reactions or mood changes. Anyone experiencing serious symptoms should seek medical attention immediately.

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Sermorelin

Sermorelin is a synthetic peptide that stimulates the body’s natural production of human growth hormone (GH), which in turn supports the creation of insulin-like growth factor 1 (IGF-1). These hormonal changes may help preserve or increase lean muscle mass, support healthy metabolism and improve body composition over time[4]. Research suggests that longer treatment periods can lead to increases in lean body mass and muscle strength, particularly in older adults, even without major changes in overall weight[4]. Since muscle tissue burns more calories than fat, maintaining or improving muscle mass can be an important part of a comprehensive weight-management plan. 

Typical Dosing Schedule

Sermorelin is typically administered as a once-daily subcutaneous injection, given about one hour before bedtime. Your exact dosing plan may vary based on your provider’s recommendations.

Side Effects

As with any prescription medication, there is the potential for side effects. Commonly reported ones may include[5]:

  • Facial flushing
  • Headache
  • Nausea
  • Pain, redness or swelling at the injection site
  • Vomiting

Serious side effects can occur, such as signs of severe allergic reaction (rash, hives, itching, difficulty breathing, tightness in the chest, swelling of the mouth, face, lips or tongue). Seek medical attention immediately if these occur.

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Liraglutide

Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist typically prescribed to help regulate blood sugar in adults and children with type 2 diabetes. 

It slows gastric emptying, which can help you feel full for longer, and influences appetite regulation centers in the brain to reduce hunger signals[6]. This combination of effects can naturally encourage eating less throughout the day without feeling deprived.

Liraglutide also suppresses glucagon secretion[7], a hormone that raises blood sugar, which may help keep blood glucose levels more stable throughout the day. Together, these effects may support gradual, sustainable weight loss when combined with healthy eating and regular physical activity under medical supervision.

Typical Dosing Schedule

Liraglutide injections are usually given as a once-daily subcutaneous injection, starting at 0.6 mg daily and increasing by 0.6 mg each week until reaching 3 mg daily by week 5[8]. Your exact schedule may vary based on your needs and your provider’s guidance. If more than three days of doses are missed, treatment is typically restarted at 0.6 mg and gradually increased again.

Side Effects

As with any prescription medication, there is the potential for side effects. Commonly reported ones may include[9]:

  • Nausea
  • Diarrhea
  • Vomiting
  • Decreased appetite
  • Constipation
  • Indigestion or upset stomach
  • Headache
  • Injection site reactions
  • Fatigue
  • Dizziness

Less commonly, liraglutide may be associated with conditions such as thyroid changes, gallbladder issues, pancreatitis, kidney problems or mood changes. While these are rare, it’s important to be aware of the signs and contact a healthcare provider if they occur.

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How to Decide Which Weight Loss Solution is Right for You 

Because each person’s health history, goals and response to therapy are unique, it’s important to work closely with a licensed provider before starting any medication. A physician can evaluate your needs, monitor progress and make adjustments as needed.

While these medications may help support weight management, they are not a replacement for healthy lifestyle choices. Lasting results typically come from combining a medication plan with balanced nutrition, regular physical activity and other positive daily habits.

Smiling young woman jogging outdoors in a purple athletic shirt and black shorts, with trees and buildings in the background.

Take the Next Step Toward Your Weight Goals With Olympia

Finding the right weight-loss medication isn’t just about following trends — it’s about choosing a solution that fits your body, your lifestyle and your long-term health. Naltrexone, sermorelin and liraglutide* each offer unique potential benefits when prescribed by a licensed provider and paired with sustainable lifestyle changes.

Olympia compounds all three of these medications to exacting quality standards, ensuring they are prepared for use as part of a medically supervised plan. With the right guidance, these therapies may help you work toward managing a healthy weight.

Contact our team today to discuss how these options might fit into your weight-management strategy.

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*Liraglutide is a compounded drug prepared in accordance with the Food, Drug, and Cosmetic Act by an FDA-registered 503B outsourcing facility. It is intended to address current drug shortages as identified by the U.S. Food and Drug Administration. This compounded preparation is not approved by the FDA; however, it is produced under strict compliance with applicable federal and state regulations.

Sources:

1. Yeomans MR, Gray RW. Opioid peptides and the control of human ingestive behaviour. Neurosci Biobehav Rev. 2002 Oct;26(6):713-28. doi: 10.1016/s0149-7634(02)00041-6. PMID: 12479844.

2. Mason AE, Laraia B, Daubenmier J, Hecht FM, Lustig RH, Puterman E, Adler N, Dallman M, Kiernan M, Gearhardt AN, Epel ES. Putting the brakes on the “drive to eat”: Pilot effects of naltrexone and reward-based eating on food cravings among obese women. Eat Behav. 2015 Dec;19:53-6. doi: 10.1016/j.eatbeh.2015.06.008. Epub 2015 Jul 2. PMID: 26164674; PMCID: PMC4644449.

3. Drugs.com [Internet]. [cited 2025 Aug 14]. Naltrexone: Uses, Dosage, Side Effects, Warnings. Available from: https://www.drugs.com/naltrexone.html

4. Sinha DK, Balasubramanian A, Tatem AJ, Rivera-Mirabal J, Yu J, Kovac J, Pastuszak AW, Lipshultz LI. Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. Transl Androl Urol. 2020 Mar;9(Suppl 2):S149-S159. doi: 10.21037/tau.2019.11.30. PMID: 32257855; PMCID: PMC7108996.

5. Sermorelin acetate: Indications, Side Effects, Warnings – Drugs.com [Internet]. [cited 2025 Aug 14]. Available from: https://www.drugs.com/cdi/sermorelin-acetate.html

6. Cerillo JL, Parmar M. Liraglutide. [Updated 2024 Oct 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK608007/

7. Clark L. GLP-1 receptor agonists: A review of glycemic benefits and beyond. JAAPA. 2024 Apr 1;37(4):1-4. doi: 10.1097/01.JAA.0001007388.97793.41. Epub 2024 Mar 26. PMID: 38531038.

8. Cerillo JL, Parmar M. Liraglutide. [Updated 2024 Oct 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK608007/

9. Drugs.com [Internet]. [cited 2025 Aug 14]. Liraglutide: Uses, Dosage, Side Effects, Warnings. Available from: https://www.drugs.com/liraglutide.html

What to Do When Erectile Dysfunction Medications Aren’t Working

Smiling man in casual clothing sitting on an exam table while a male doctor in a white coat holds a clipboard, both engaged in friendly conversation in a bright medical office.

You’ve tried the standard erectile dysfunction (ED) pills your doctor prescribed, but they’re not giving you the results you expected. Maybe they worked at first and then faded, or maybe they never worked at all. It’s a common problem that can leave you wondering what’s next.

Oral medications like sildenafil (Generic Viagra), tadalafil (Generic Cialis), vardenafil and avanafil are often prescribed as the first-line treatment for ED. However, they don’t work for everyone. Research suggests that 30-35% of patients don’t respond initially[1], and others may find that the medications show fewer results over time.

If that sounds familiar, you’re not alone, and you’re not out of options. This guide breaks down common reasons these medications are not working, signs to watch for and practical next steps. You’ll also learn about other options like injectable ED medications and how to decide what’s right for you with the help of a licensed provider.

How Are PDE5 Inhibitors Supposed to Work?

Oral ED medications like sildenafil, tadalafil, vardenafil and avanafil belong to a class of drugs known as PDE5 inhibitors. PDE5 inhibitors are designed to improve symptoms of ED by increasing blood flow to the penis. They do this by blocking the enzyme phosphodiesterase type 5 (PDE5), which normally breaks down a chemical called cGMP that relaxes blood vessels. With more cGMP available, the blood vessels in the penis stay open longer, which can make erections easier to maintain. 

Signs Your ED Medication Isn’t Working

While many men have success using PDE-5 inhibitors, some may not have the same results. Signs the medications might not be working as intended include:

  • Weaker or less reliable erections even when you take your medication as directed.
  • Longer onset time or inconsistent results, despite following the same dosing schedule and conditions.
  • No improvement even after increasing to the maximum tolerated dose under medical supervision.
  • Side effects outweigh the benefits, such as persistent headaches, indigestion, nasal congestion or vision changes.
  • Loss of confidence, frustration or anxiety related to sexual performance.

If your ED medication isn’t working, it’s not necessarily a dead end. It may be a signal to explore other therapies with a provider.

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Why ED Meds Sometimes Don’t Work

While oral ED medications are beneficial for many men, they may show weaker or no results over time. This can happen for a variety of reasons, such as:

  1. Improper Use or Poor Patient Education

One of the most common reasons ED medications aren’t working is that they aren’t used correctly. Many men don’t realize that these medications require timing, sexual stimulation and (in some cases) an empty stomach to work as intended. Taking the pill too soon before sex, with a heavy meal or without adequate stimulation can all reduce efficacy[2].

Research suggests that more than half of men who don’t initially respond to sildenafil are using it incorrectly, whether through low dosing, poor timing or giving up after just a few attempts[3].

  1. Inadequate Dosage or Dose Not Optimized

Some patients may not respond to oral ED medications because the dose is too low or because the provider hasn’t yet titrated to the maximum level[2]. It’s also common for patients to try a low dose once or twice, see no results, and discontinue use altogether.

  1. Comorbidities and Disease Progression

Health conditions like cardiovascular disease, metabolic syndrome and high cholesterol can all reduce how well PDE5 inhibitors work[3]. In many cases, these underlying issues worsen over time, making ED medications stop working even if they previously worked well. 

  1. Hypogonadism (Low Testosterone)

For some men, low testosterone levels may be the reason their ED medication isn’t working. PDE5 inhibitors rely in part on healthy androgen levels to function properly. Without sufficient testosterone, even high doses of sildenafil or tadalafil may fall flat. Research suggests that men with low baseline testosterone were much more likely to regain erectile function after adding testosterone therapy to their care plan[2]

  1. Incorrect Expectations or Psychological Factors

Not all erectile dysfunction is physical. Mental health and your emotional state can affect how well medications work. Anxiety, depression, fear of failure or unresolved relationship stress can suppress the body’s natural erectile response regardless of medication[2]. Unrealistic expectations are another issue: some men expect instant, effortless results or assume the drug will work like an aphrodisiac[3], which it doesn’t. 

What to Do Next

If your erectile dysfunction medication isn’t working the way it is designed to, don’t panic — and don’t self-adjust your dosage. Many men find that the issue is simply how the medication is being taken. Timing, food intake and the need for sexual stimulation can all affect how well ED medications work. Before assuming a medication has failed, make sure you’re following your provider’s instructions closely and giving the medication a fair chance.

If problems persist, the next step is to talk to a licensed provider. They can help identify any underlying issues, such as low testosterone, medication interactions or other health conditions, and determine the best course of action. This might include adjusting your dosage or trying another treatment. No matter the cause, working directly with a medical professional is the best way to get your care plan back on track.

Close-up of a clear medical vial and syringe on a light blue background, filled with a transparent liquid.

What Are Your Options After Oral ED Meds?

When PDE5 inhibitors don’t work, injectable therapies may be prescribed as the next step. These second-line treatment options, called intracavernosal injections, deliver medication directly into the base of the penis, bypassing the need for systemic absorption.

This approach can be done with single vasoactive agents or combination therapies that blend multiple vasoactive ingredients. These agents work by affecting blood vessel size to relax smooth muscle in the penis and increase blood flow for an erection[4]. Combination injections are prepared by compounding pharmacies and adjusted to a patient’s needs by a licensed provider.  

Two of the most common combination therapies are Trimix and Bimix. Here’s a breakdown of what’s in them:

  • Papaverine (Bimix and Trimix): A vasodilator that relaxes blood vessels to improve flow.
  • Phentolamine (Bimix and Trimix): Helps maintain an erection by reducing the outflow of blood.
  • Alprostadil (Trimix only): Boosts blood flow and helps enhance firmness and erection duration.

Intracavernosal injection therapy has shown high success rates, even among patients who don’t find success with oral ED medications. Research suggests that combination therapies may help up to 94% of patients achieve erections firm enough for intercourse[5].

Trimix vs. Bimix

While Trimix injections may offer higher potency due to their inclusion of alprostadil, they’re associated with a higher, but not statistically significant, risk of priapism and pain, particularly early in treatment[6]. Bimix tends to be better tolerated in some patients, but overall satisfaction and complication rates are similar when dosing is carefully managed[6].

Research suggests Trimix may help improve ED symptoms in up to 92% of men who don’t respond to oral ED medications[2]. Bimix, while generally considered less potent, may help improve symptoms of mild to moderate ED[7].

Trimix offers a more aggressive approach for men who don’t respond to oral ED medications or Bimix. Bimix may be a preferred first step for patients looking to avoid alprostadil-related pain, while still achieving strong results. A provider can help determine the most appropriate option based on your medical history, goals and comfort level with injection therapy.

Happy couple sitting together on a bed, with the woman hugging the man from behind and both smiling warmly in a relaxed, intimate moment.

Take the Next Step With Olympia’s Injectable ED Therapies

If your ED medication isn’t working as well as it once did, it doesn’t have to mean the end of your options. By working closely with a licensed provider, you can explore adjustments to your current plan or move to other therapies that better match your needs. 

For many men, injectable ED medications offer a reliable next step when pills aren’t enough. Olympia Pharmacy compounds both formulations with precision under strict Current Good Manufacturing Practice (cGMP) standards. 

Ready to explore ED treatment options beyond oral medications? Talk to your provider about whether Olympia’s compounded injection therapies could be right for you.

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Resources

1. Lee M, Sharifi R. Non-invasive Management Options for Erectile Dysfunction When a Phosphodiesterase Type 5 Inhibitor Fails. Drugs Aging. 2018 Mar;35(3):175-187. doi: 10.1007/s40266-018-0528-4. PMID: 29464656.

2. McMahon CN, Smith CJ, Shabsigh R. Treating erectile dysfunction when PDE5 inhibitors fail. BMJ. 2006 Mar 11;332(7541):589-92. doi: 10.1136/bmj.332.7541.589. PMID: 16528082; PMCID: PMC1397768.

3. Park NC, Kim TN, Park HJ. Treatment Strategy for Non-Responders to PDE5 Inhibitors. World J Mens Health. 2013 Apr;31(1):31-5. doi: 10.5534/wjmh.2013.31.1.31. Epub 2013 Apr 23. PMID: 23658863; PMCID: PMC3640150.

4. Kedia GT, Ückert S, Tsikas D, Becker AJ, Kuczyk MA, Bannowsky A. The Use of Vasoactive Drugs in the Treatment of Male Erectile Dysfunction: Current Concepts. J Clin Med. 2020 Sep 16;9(9):2987. doi: 10.3390/jcm9092987. PMID: 32947804; PMCID: PMC7564459.

5. Leslie SW, Sooriyamoorthy T. Erectile Dysfunction. [Updated 2024 Jan 9]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK562253/

6. Bernie HL, Segal R, Le B, Burnett A, Bivalacqua TJ. An Empirical vs Risk-Based Approach Algorithm to Intracavernosal Injection Therapy: A Prospective Study. Sex Med. 2017 Mar;5(1):e31-e36. doi: 10.1016/j.esxm.2016.08.001. PMID: 28190453; PMCID: PMC5302379.

7. Abdullahi M. Intracavernous Self-injection of Papaverine Plus Chlorpromazine (Bimix) for the Treatment of Erectile Dysfunction. Niger Postgrad Med J. 2025 Jul 1;32(3):192-196. doi: 10.4103/npmj.npmj_299_24. Epub 2025 Aug 1. PMID: 40745875.

Top 10 IV Therapy Products of 2025

Top 10 IV Therapy Products of 2025

IV therapy, short for intravenous therapy, is a wellness trend where vitamins, minerals, and other nutrients are delivered directly into your bloodstream through an IV drip. This allows your body to absorb nutrients faster and more efficiently by bypassing the digestive system. People often visit IV therapy clinics in search of regimens designed for quick hydration, an energy boost, immune support, or recovery after workouts. Popular mixes, or cocktails, contain various ingredients tailored to a wide range of wellness goals.

1. NAD+ (Nicotinamide Adenine Dinucleotide)

 

What it is: NAD+ is a coenzyme found in every living cell. It supports cellular reactions involved in energy production, metabolism, DNA repair, and cell aging.

IV use: People seek NAD+ infusions for potential longevity (anti-aging) benefits, enhanced energy, and clearer mental function.

2. Glutathione

What it is: Known as the body’s master antioxidant, glutathione’s role in the body is to help neutralize free radicals and toxins.

IV use: When administered intravenously, glutathione is often included in regimens focused on detoxification and immune support. These routines are designed with the idea of combatting oxidative stress and cellular health support in mind.

3. Ascorbic Acid (Vitamin C)

What it is: In the body, Vitamin C is a water-soluble vitamin that plays an essential role in collagen production, antioxidant protection, and immune function.

IV use: When incorporated into an IV therapy routine, Ascorbic Acid is included in regimens that focus on promoting immune support, skin health, and antioxidant protection.

4. Vita Complex (B-Complex Vitamins)

What it is: The Vita-Complex blend is comprised of multiple essential B vitamins: thiamine (B1), riboflavin 5 phosphate (B2), niacinamide (B3), dexpanthenol (B5), and pyridoxine (B6). When naturally occurring in the body, these vitamins play a role in aiding the conversion of food into usable energy.

IV use: When used as a part of a regimen for IV therapy, Vita-Complex’s blend of B vitamins make it a popular choice for routines that are designed for metabolism, energy production, and promoting healthy skin, hair, and nails.

5. Myers’ Cocktail

What it is: Named after Dr. John Myers, this classic IV nutrient blend contains a plethora of minerals and vitamins. This includes magnesium, calcium, vitamin C, and B vitamins.

IV use: Because of its versatility and range of vitamins, Myers’ Cocktail sees high usage in IV therapy regimens intended for supporting general wellness, energy levels, and immune health.

6. Zinc Sulfate

What it is: Zinc is a mineral found in the body that has an essential part to play in supporting immune function, wound healing, and metabolic processes.

IV use: When incorporated into IV therapy infusions, Zinc Sulfate is typically included in routines designed for immune support and recovery.

7. Amino Blend (Amino Acids)

What it is: The Olympia Vita-Complex isn’t the only signature blend we carry. In addition, we also offer a mixture of amino acids known as the Amino Blend. This formulation is composed of Arginine, L-Citrulline, Proline, and L-Lysine. When naturally occurring in the body, amino acids play a fundamental role in the production and maintenance of energy, as well as muscle repair, metabolism, and overall recovery.

IV use: In IV therapy regimens that aim to address athletic recovery and muscle health, the Amino Blend is a popular choice.

8. Magnesium Chloride

What it is: As a naturally occurring electrolyte, magnesium is important for muscle and nerve function, relaxation, and cardiovascular health. Additionally, research suggests that magnesium plays an important role in the regulation of sleep in the body.

IV use: Magnesium Chloride, a formulation of the electrolyte compounded for intravenous use, is often included in cocktails that are designed with relaxation, stress relief, and muscle recovery in mind.

9. Biotin (Vitamin B7)

What it is: Alongside the B vitamins featured in our Vita-Complex, another popular B vitamin in IV Therapy is biotin, or vitamin B7. When naturally occurring in the body, biotin is involved in metabolism and the maintenance of healthy hair, skin, and nails.

IV use: Featured in beauty-focused IVs for supporting hair, nail, and skin health. Olympia Pharmacy Biotin

10. L-Taurine

What it is: Among the various amino acids is L-Taurine. When found in the body, L-Taurine aids in the support of electrolyte balance, antioxidant protection, muscle function, and overall hydration. Additionally, L-Taurine is an agonist of gamma aminobutyric acid, or GABA, which is known for aiding in the control of mood, sleep, and anxiety.

IV use: In IV regimens designed with athletic performance and recovery in mind, L-Taurine is a popular choice. Often included in drips targeting athletic performance, recovery, and general vitality.

Bonus: Post-Hangover IV Picks

With IV therapy having roots in addressing hydration, numerous regimens and cocktails have been developed that are intended for hangover recovery. If you’re still reeling from a fun night out, it may be worth considering infusions developed with replenishing your body. For routines like these, many popular picks you may see are magnesium chloride, ascorbic acid, zinc sulfate, and our Vita-Complex!

Factors to Consider

Bear in mind that IV therapy may not be suitable for everyone. Always consult your healthcare provider before choosing IV therapies to ensure they match your personal health needs and conditions. The information presented here is for educational purposes only, and should not substitute or replace advice from your medical provider.