3 Weight Loss Injections and Tablets You Might Not Know About

Close-up of a person in a blue shirt and jeans administering a subcutaneous injection into their abdomen using a syringe.

Weight loss is rarely a one-size-fits-all process. Even with the right balance of diet and exercise, many people find themselves hitting plateaus or struggling with persistent cravings or inconsistent results. When that happens, some explore medical options, and injections have become a leading choice in recent years. While some weight-loss injections have captured the spotlight in recent years, they’re not the only options available.

There are other therapies that, under the guidance of a licensed provider, may help you lose weight. In this blog, we’ll explore three such options: naltrexone, sermorelin and liraglutide. Let’s take a closer look at what they are, how they work and when they might fit into a comprehensive weight management plan.

Naltrexone

Naltrexone is an opioid receptor blocker that has been studied for its effects on eating behavior. It may influence the brain’s reward pathways, which are tied to cravings for rich, indulgent foods[1], like sweets, fried snacks or fast food. Research suggests it can make food feel less rewarding for some people, which may help reduce “reward-driven” eating patterns[2]. However, it does not consistently lower overall craving intensity, and its effects can vary between individuals.

This suggests naltrexone may be more relevant for people whose eating habits are strongly influenced by the pleasure of eating, rather than by physiological hunger cues. While it is not considered a stand-alone treatment for weight loss, naltrexone may be prescribed in combination with other therapies as part of a broader weight management plan overseen by a licensed provider.

Typical Dosing Schedule

Naltrexone is commonly prescribed as a once-daily oral tablet. Your exact dosage and schedule will depend on your provider’s guidance and your specific needs.

Side Effects

As with any prescription medication, there is the potential for side effects. Commonly reported ones may include[3]:

  • Nausea, vomiting or loss of appetite
  • Joint or muscle pain
  • Headache, dizziness or drowsiness
  • Trouble sleeping
  • Cold or allergy-like symptoms (stuffy nose, sore throat)

More serious side effects can occur, such as signs of liver problems, allergic reactions or mood changes. Anyone experiencing serious symptoms should seek medical attention immediately.

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Sermorelin

Sermorelin is a synthetic peptide that stimulates the body’s natural production of human growth hormone (GH), which in turn supports the creation of insulin-like growth factor 1 (IGF-1). These hormonal changes may help preserve or increase lean muscle mass, support healthy metabolism and improve body composition over time[4]. Research suggests that longer treatment periods can lead to increases in lean body mass and muscle strength, particularly in older adults, even without major changes in overall weight[4]. Since muscle tissue burns more calories than fat, maintaining or improving muscle mass can be an important part of a comprehensive weight-management plan. 

Typical Dosing Schedule

Sermorelin is typically administered as a once-daily subcutaneous injection, given about one hour before bedtime. Your exact dosing plan may vary based on your provider’s recommendations.

Side Effects

As with any prescription medication, there is the potential for side effects. Commonly reported ones may include[5]:

  • Facial flushing
  • Headache
  • Nausea
  • Pain, redness or swelling at the injection site
  • Vomiting

Serious side effects can occur, such as signs of severe allergic reaction (rash, hives, itching, difficulty breathing, tightness in the chest, swelling of the mouth, face, lips or tongue). Seek medical attention immediately if these occur.

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Liraglutide

Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist typically prescribed to help regulate blood sugar in adults and children with type 2 diabetes. 

It slows gastric emptying, which can help you feel full for longer, and influences appetite regulation centers in the brain to reduce hunger signals[6]. This combination of effects can naturally encourage eating less throughout the day without feeling deprived.

Liraglutide also suppresses glucagon secretion[7], a hormone that raises blood sugar, which may help keep blood glucose levels more stable throughout the day. Together, these effects may support gradual, sustainable weight loss when combined with healthy eating and regular physical activity under medical supervision.

Typical Dosing Schedule

Liraglutide injections are usually given as a once-daily subcutaneous injection, starting at 0.6 mg daily and increasing by 0.6 mg each week until reaching 3 mg daily by week 5[8]. Your exact schedule may vary based on your needs and your provider’s guidance. If more than three days of doses are missed, treatment is typically restarted at 0.6 mg and gradually increased again.

Side Effects

As with any prescription medication, there is the potential for side effects. Commonly reported ones may include[9]:

  • Nausea
  • Diarrhea
  • Vomiting
  • Decreased appetite
  • Constipation
  • Indigestion or upset stomach
  • Headache
  • Injection site reactions
  • Fatigue
  • Dizziness

Less commonly, liraglutide may be associated with conditions such as thyroid changes, gallbladder issues, pancreatitis, kidney problems or mood changes. While these are rare, it’s important to be aware of the signs and contact a healthcare provider if they occur.

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How to Decide Which Weight Loss Solution is Right for You 

Because each person’s health history, goals and response to therapy are unique, it’s important to work closely with a licensed provider before starting any medication. A physician can evaluate your needs, monitor progress and make adjustments as needed.

While these medications may help support weight management, they are not a replacement for healthy lifestyle choices. Lasting results typically come from combining a medication plan with balanced nutrition, regular physical activity and other positive daily habits.

Smiling young woman jogging outdoors in a purple athletic shirt and black shorts, with trees and buildings in the background.

Take the Next Step Toward Your Weight Goals With Olympia

Finding the right weight-loss medication isn’t just about following trends — it’s about choosing a solution that fits your body, your lifestyle and your long-term health. Naltrexone, sermorelin and liraglutide* each offer unique potential benefits when prescribed by a licensed provider and paired with sustainable lifestyle changes.

Olympia compounds all three of these medications to exacting quality standards, ensuring they are prepared for use as part of a medically supervised plan. With the right guidance, these therapies may help you work toward managing a healthy weight.

Contact our team today to discuss how these options might fit into your weight-management strategy.

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*Liraglutide is a compounded drug prepared in accordance with the Food, Drug, and Cosmetic Act by an FDA-registered 503B outsourcing facility. It is intended to address current drug shortages as identified by the U.S. Food and Drug Administration. This compounded preparation is not approved by the FDA; however, it is produced under strict compliance with applicable federal and state regulations.

Sources:

1. Yeomans MR, Gray RW. Opioid peptides and the control of human ingestive behaviour. Neurosci Biobehav Rev. 2002 Oct;26(6):713-28. doi: 10.1016/s0149-7634(02)00041-6. PMID: 12479844.

2. Mason AE, Laraia B, Daubenmier J, Hecht FM, Lustig RH, Puterman E, Adler N, Dallman M, Kiernan M, Gearhardt AN, Epel ES. Putting the brakes on the “drive to eat”: Pilot effects of naltrexone and reward-based eating on food cravings among obese women. Eat Behav. 2015 Dec;19:53-6. doi: 10.1016/j.eatbeh.2015.06.008. Epub 2015 Jul 2. PMID: 26164674; PMCID: PMC4644449.

3. Drugs.com [Internet]. [cited 2025 Aug 14]. Naltrexone: Uses, Dosage, Side Effects, Warnings. Available from: https://www.drugs.com/naltrexone.html

4. Sinha DK, Balasubramanian A, Tatem AJ, Rivera-Mirabal J, Yu J, Kovac J, Pastuszak AW, Lipshultz LI. Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. Transl Androl Urol. 2020 Mar;9(Suppl 2):S149-S159. doi: 10.21037/tau.2019.11.30. PMID: 32257855; PMCID: PMC7108996.

5. Sermorelin acetate: Indications, Side Effects, Warnings – Drugs.com [Internet]. [cited 2025 Aug 14]. Available from: https://www.drugs.com/cdi/sermorelin-acetate.html

6. Cerillo JL, Parmar M. Liraglutide. [Updated 2024 Oct 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK608007/

7. Clark L. GLP-1 receptor agonists: A review of glycemic benefits and beyond. JAAPA. 2024 Apr 1;37(4):1-4. doi: 10.1097/01.JAA.0001007388.97793.41. Epub 2024 Mar 26. PMID: 38531038.

8. Cerillo JL, Parmar M. Liraglutide. [Updated 2024 Oct 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK608007/

9. Drugs.com [Internet]. [cited 2025 Aug 14]. Liraglutide: Uses, Dosage, Side Effects, Warnings. Available from: https://www.drugs.com/liraglutide.html

What to Do When Erectile Dysfunction Medications Aren’t Working

Smiling man in casual clothing sitting on an exam table while a male doctor in a white coat holds a clipboard, both engaged in friendly conversation in a bright medical office.

You’ve tried the standard erectile dysfunction (ED) pills your doctor prescribed, but they’re not giving you the results you expected. Maybe they worked at first and then faded, or maybe they never worked at all. It’s a common problem that can leave you wondering what’s next.

Oral medications like sildenafil (Generic Viagra), tadalafil (Generic Cialis), vardenafil and avanafil are often prescribed as the first-line treatment for ED. However, they don’t work for everyone. Research suggests that 30-35% of patients don’t respond initially[1], and others may find that the medications show fewer results over time.

If that sounds familiar, you’re not alone, and you’re not out of options. This guide breaks down common reasons these medications are not working, signs to watch for and practical next steps. You’ll also learn about other options like injectable ED medications and how to decide what’s right for you with the help of a licensed provider.

How Are PDE5 Inhibitors Supposed to Work?

Oral ED medications like sildenafil, tadalafil, vardenafil and avanafil belong to a class of drugs known as PDE5 inhibitors. PDE5 inhibitors are designed to improve symptoms of ED by increasing blood flow to the penis. They do this by blocking the enzyme phosphodiesterase type 5 (PDE5), which normally breaks down a chemical called cGMP that relaxes blood vessels. With more cGMP available, the blood vessels in the penis stay open longer, which can make erections easier to maintain. 

Signs Your ED Medication Isn’t Working

While many men have success using PDE-5 inhibitors, some may not have the same results. Signs the medications might not be working as intended include:

  • Weaker or less reliable erections even when you take your medication as directed.
  • Longer onset time or inconsistent results, despite following the same dosing schedule and conditions.
  • No improvement even after increasing to the maximum tolerated dose under medical supervision.
  • Side effects outweigh the benefits, such as persistent headaches, indigestion, nasal congestion or vision changes.
  • Loss of confidence, frustration or anxiety related to sexual performance.

If your ED medication isn’t working, it’s not necessarily a dead end. It may be a signal to explore other therapies with a provider.

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Why ED Meds Sometimes Don’t Work

While oral ED medications are beneficial for many men, they may show weaker or no results over time. This can happen for a variety of reasons, such as:

  1. Improper Use or Poor Patient Education

One of the most common reasons ED medications aren’t working is that they aren’t used correctly. Many men don’t realize that these medications require timing, sexual stimulation and (in some cases) an empty stomach to work as intended. Taking the pill too soon before sex, with a heavy meal or without adequate stimulation can all reduce efficacy[2].

Research suggests that more than half of men who don’t initially respond to sildenafil are using it incorrectly, whether through low dosing, poor timing or giving up after just a few attempts[3].

  1. Inadequate Dosage or Dose Not Optimized

Some patients may not respond to oral ED medications because the dose is too low or because the provider hasn’t yet titrated to the maximum level[2]. It’s also common for patients to try a low dose once or twice, see no results, and discontinue use altogether.

  1. Comorbidities and Disease Progression

Health conditions like cardiovascular disease, metabolic syndrome and high cholesterol can all reduce how well PDE5 inhibitors work[3]. In many cases, these underlying issues worsen over time, making ED medications stop working even if they previously worked well. 

  1. Hypogonadism (Low Testosterone)

For some men, low testosterone levels may be the reason their ED medication isn’t working. PDE5 inhibitors rely in part on healthy androgen levels to function properly. Without sufficient testosterone, even high doses of sildenafil or tadalafil may fall flat. Research suggests that men with low baseline testosterone were much more likely to regain erectile function after adding testosterone therapy to their care plan[2]

  1. Incorrect Expectations or Psychological Factors

Not all erectile dysfunction is physical. Mental health and your emotional state can affect how well medications work. Anxiety, depression, fear of failure or unresolved relationship stress can suppress the body’s natural erectile response regardless of medication[2]. Unrealistic expectations are another issue: some men expect instant, effortless results or assume the drug will work like an aphrodisiac[3], which it doesn’t. 

What to Do Next

If your erectile dysfunction medication isn’t working the way it is designed to, don’t panic — and don’t self-adjust your dosage. Many men find that the issue is simply how the medication is being taken. Timing, food intake and the need for sexual stimulation can all affect how well ED medications work. Before assuming a medication has failed, make sure you’re following your provider’s instructions closely and giving the medication a fair chance.

If problems persist, the next step is to talk to a licensed provider. They can help identify any underlying issues, such as low testosterone, medication interactions or other health conditions, and determine the best course of action. This might include adjusting your dosage or trying another treatment. No matter the cause, working directly with a medical professional is the best way to get your care plan back on track.

Close-up of a clear medical vial and syringe on a light blue background, filled with a transparent liquid.

What Are Your Options After Oral ED Meds?

When PDE5 inhibitors don’t work, injectable therapies may be prescribed as the next step. These second-line treatment options, called intracavernosal injections, deliver medication directly into the base of the penis, bypassing the need for systemic absorption.

This approach can be done with single vasoactive agents or combination therapies that blend multiple vasoactive ingredients. These agents work by affecting blood vessel size to relax smooth muscle in the penis and increase blood flow for an erection[4]. Combination injections are prepared by compounding pharmacies and adjusted to a patient’s needs by a licensed provider.  

Two of the most common combination therapies are Trimix and Bimix. Here’s a breakdown of what’s in them:

  • Papaverine (Bimix and Trimix): A vasodilator that relaxes blood vessels to improve flow.
  • Phentolamine (Bimix and Trimix): Helps maintain an erection by reducing the outflow of blood.
  • Alprostadil (Trimix only): Boosts blood flow and helps enhance firmness and erection duration.

Intracavernosal injection therapy has shown high success rates, even among patients who don’t find success with oral ED medications. Research suggests that combination therapies may help up to 94% of patients achieve erections firm enough for intercourse[5].

Trimix vs. Bimix

While Trimix injections may offer higher potency due to their inclusion of alprostadil, they’re associated with a higher, but not statistically significant, risk of priapism and pain, particularly early in treatment[6]. Bimix tends to be better tolerated in some patients, but overall satisfaction and complication rates are similar when dosing is carefully managed[6].

Research suggests Trimix may help improve ED symptoms in up to 92% of men who don’t respond to oral ED medications[2]. Bimix, while generally considered less potent, may help improve symptoms of mild to moderate ED[7].

Trimix offers a more aggressive approach for men who don’t respond to oral ED medications or Bimix. Bimix may be a preferred first step for patients looking to avoid alprostadil-related pain, while still achieving strong results. A provider can help determine the most appropriate option based on your medical history, goals and comfort level with injection therapy.

Happy couple sitting together on a bed, with the woman hugging the man from behind and both smiling warmly in a relaxed, intimate moment.

Take the Next Step With Olympia’s Injectable ED Therapies

If your ED medication isn’t working as well as it once did, it doesn’t have to mean the end of your options. By working closely with a licensed provider, you can explore adjustments to your current plan or move to other therapies that better match your needs. 

For many men, injectable ED medications offer a reliable next step when pills aren’t enough. Olympia Pharmacy compounds both formulations with precision under strict Current Good Manufacturing Practice (cGMP) standards. 

Ready to explore ED treatment options beyond oral medications? Talk to your provider about whether Olympia’s compounded injection therapies could be right for you.

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Resources

1. Lee M, Sharifi R. Non-invasive Management Options for Erectile Dysfunction When a Phosphodiesterase Type 5 Inhibitor Fails. Drugs Aging. 2018 Mar;35(3):175-187. doi: 10.1007/s40266-018-0528-4. PMID: 29464656.

2. McMahon CN, Smith CJ, Shabsigh R. Treating erectile dysfunction when PDE5 inhibitors fail. BMJ. 2006 Mar 11;332(7541):589-92. doi: 10.1136/bmj.332.7541.589. PMID: 16528082; PMCID: PMC1397768.

3. Park NC, Kim TN, Park HJ. Treatment Strategy for Non-Responders to PDE5 Inhibitors. World J Mens Health. 2013 Apr;31(1):31-5. doi: 10.5534/wjmh.2013.31.1.31. Epub 2013 Apr 23. PMID: 23658863; PMCID: PMC3640150.

4. Kedia GT, Ückert S, Tsikas D, Becker AJ, Kuczyk MA, Bannowsky A. The Use of Vasoactive Drugs in the Treatment of Male Erectile Dysfunction: Current Concepts. J Clin Med. 2020 Sep 16;9(9):2987. doi: 10.3390/jcm9092987. PMID: 32947804; PMCID: PMC7564459.

5. Leslie SW, Sooriyamoorthy T. Erectile Dysfunction. [Updated 2024 Jan 9]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK562253/

6. Bernie HL, Segal R, Le B, Burnett A, Bivalacqua TJ. An Empirical vs Risk-Based Approach Algorithm to Intracavernosal Injection Therapy: A Prospective Study. Sex Med. 2017 Mar;5(1):e31-e36. doi: 10.1016/j.esxm.2016.08.001. PMID: 28190453; PMCID: PMC5302379.

7. Abdullahi M. Intracavernous Self-injection of Papaverine Plus Chlorpromazine (Bimix) for the Treatment of Erectile Dysfunction. Niger Postgrad Med J. 2025 Jul 1;32(3):192-196. doi: 10.4103/npmj.npmj_299_24. Epub 2025 Aug 1. PMID: 40745875.

Top 10 IV Therapy Products of 2025

Top 10 IV Therapy Products of 2025

IV therapy, short for intravenous therapy, is a wellness trend where vitamins, minerals, and other nutrients are delivered directly into your bloodstream through an IV drip. This allows your body to absorb nutrients faster and more efficiently by bypassing the digestive system. People often visit IV therapy clinics in search of regimens designed for quick hydration, an energy boost, immune support, or recovery after workouts. Popular mixes, or cocktails, contain various ingredients tailored to a wide range of wellness goals.

1. NAD+ (Nicotinamide Adenine Dinucleotide)

 

What it is: NAD+ is a coenzyme found in every living cell. It supports cellular reactions involved in energy production, metabolism, DNA repair, and cell aging.

IV use: People seek NAD+ infusions for potential longevity (anti-aging) benefits, enhanced energy, and clearer mental function.

2. Glutathione

What it is: Known as the body’s master antioxidant, glutathione’s role in the body is to help neutralize free radicals and toxins.

IV use: When administered intravenously, glutathione is often included in regimens focused on detoxification and immune support. These routines are designed with the idea of combatting oxidative stress and cellular health support in mind.

3. Ascorbic Acid (Vitamin C)

What it is: In the body, Vitamin C is a water-soluble vitamin that plays an essential role in collagen production, antioxidant protection, and immune function.

IV use: When incorporated into an IV therapy routine, Ascorbic Acid is included in regimens that focus on promoting immune support, skin health, and antioxidant protection.

4. Vita Complex (B-Complex Vitamins)

What it is: The Vita-Complex blend is comprised of multiple essential B vitamins: thiamine (B1), riboflavin 5 phosphate (B2), niacinamide (B3), dexpanthenol (B5), and pyridoxine (B6). When naturally occurring in the body, these vitamins play a role in aiding the conversion of food into usable energy.

IV use: When used as a part of a regimen for IV therapy, Vita-Complex’s blend of B vitamins make it a popular choice for routines that are designed for metabolism, energy production, and promoting healthy skin, hair, and nails.

5. Myers’ Cocktail

What it is: Named after Dr. John Myers, this classic IV nutrient blend contains a plethora of minerals and vitamins. This includes magnesium, calcium, vitamin C, and B vitamins.

IV use: Because of its versatility and range of vitamins, Myers’ Cocktail sees high usage in IV therapy regimens intended for supporting general wellness, energy levels, and immune health.

6. Zinc Sulfate

What it is: Zinc is a mineral found in the body that has an essential part to play in supporting immune function, wound healing, and metabolic processes.

IV use: When incorporated into IV therapy infusions, Zinc Sulfate is typically included in routines designed for immune support and recovery.

7. Amino Blend (Amino Acids)

What it is: The Olympia Vita-Complex isn’t the only signature blend we carry. In addition, we also offer a mixture of amino acids known as the Amino Blend. This formulation is composed of Arginine, L-Citrulline, Proline, and L-Lysine. When naturally occurring in the body, amino acids play a fundamental role in the production and maintenance of energy, as well as muscle repair, metabolism, and overall recovery.

IV use: In IV therapy regimens that aim to address athletic recovery and muscle health, the Amino Blend is a popular choice.

8. Magnesium Chloride

What it is: As a naturally occurring electrolyte, magnesium is important for muscle and nerve function, relaxation, and cardiovascular health. Additionally, research suggests that magnesium plays an important role in the regulation of sleep in the body.

IV use: Magnesium Chloride, a formulation of the electrolyte compounded for intravenous use, is often included in cocktails that are designed with relaxation, stress relief, and muscle recovery in mind.

9. Biotin (Vitamin B7)

What it is: Alongside the B vitamins featured in our Vita-Complex, another popular B vitamin in IV Therapy is biotin, or vitamin B7. When naturally occurring in the body, biotin is involved in metabolism and the maintenance of healthy hair, skin, and nails.

IV use: Featured in beauty-focused IVs for supporting hair, nail, and skin health. Olympia Pharmacy Biotin

10. L-Taurine

What it is: Among the various amino acids is L-Taurine. When found in the body, L-Taurine aids in the support of electrolyte balance, antioxidant protection, muscle function, and overall hydration. Additionally, L-Taurine is an agonist of gamma aminobutyric acid, or GABA, which is known for aiding in the control of mood, sleep, and anxiety.

IV use: In IV regimens designed with athletic performance and recovery in mind, L-Taurine is a popular choice. Often included in drips targeting athletic performance, recovery, and general vitality.

Bonus: Post-Hangover IV Picks

With IV therapy having roots in addressing hydration, numerous regimens and cocktails have been developed that are intended for hangover recovery. If you’re still reeling from a fun night out, it may be worth considering infusions developed with replenishing your body. For routines like these, many popular picks you may see are magnesium chloride, ascorbic acid, zinc sulfate, and our Vita-Complex!

Factors to Consider

Bear in mind that IV therapy may not be suitable for everyone. Always consult your healthcare provider before choosing IV therapies to ensure they match your personal health needs and conditions. The information presented here is for educational purposes only, and should not substitute or replace advice from your medical provider.

 

Ask a Pharmacist About NAD+

What Is an NAD Supplement?

NAD+, short for nicotinamide adenine dinucleotide, is a naturally occurring coenzyme found in every living cell. It’s a critical component for various functions within the body including DNA repair, cellular energy production, and the overall support of healthy aging.

When individuals are found to be deficient in NAD+, they may be prescribed NAD supplements to increase their body’s levels.

What Is NAD+ Used For?

 NAD+’s role across the body cannot be understated. The coenzyme works to convert food into ATP, the primary energy carrier for cells, that ultimately supports a wide range of needs across the body. These include:

❖Support for healthy brain and nerve function

❖Aiding in DNA repair and cellular regeneration

❖Regulating metabolism and the body’s sleep-wake cycle

NAD+’s function as a coenzyme also applies to sirtuins a family of proteins that regulate aging. Across these needs, NAD+ is viewed as a vital component to longevity and healthy aging. 

Ready for NAD Yet?

How To Increase NAD+ Levels Naturally?

NAD+ supplementation, while observed as helpful in increasing NAD+ levels across the body, isn’t the only way to influence the production and preservation of your body’s NAD+. There are a multitude of ways you can influence your NAD+ levels naturally through lifestyle choices.

❖Exercise regularly. Research suggests that routine exercise stimulates the synthesis of NAD+ in the body. Focusing on high-intensity and/or resistance training can help in preserving NAD content found within skeletal muscle.

❖Prioritize quality sleep. Even beyond the scope of NAD+, ensuring you receive a full night’s sleep is beneficial to both your body and mind. Aim to get 7-9 hours of sleep every night to give your body optimal time to recharge and reset.

❖Practice caloric moderation. Caloric moderation can passively aid in increasing NAD+ levels in the body. Research suggests that diets high in fats and sugars can result in energy overload, which decreases levels of NAD+ in the body. Practicing moderation may not just preserve natural NAD+, but can play a more active role in reaching your fitness and health goals.

❖Eat foods rich in NAD+ precursors. Fish, mushrooms, green vegetables, and whole grains have all been observed to possess the “building blocks” for NAD+ synthesis in the body. Find flavorful ways to incorporate these foods into your diet to help optimize the NAD+ your body produces.

❖Limit alcohol and processed sugar. Binge drinking alcohol can drastically reduce NAD+ levels in the body. This, alongside the energy overload that may result from a diet high in sugars, can be detrimental to preserving the NAD+ in your body.

❖Avoid chronic stress where possible. Stress is difficult to avoid, as countless factors in our daily lives can influence it. Finding ways to mitigate and reduce stress isn’t just good for your NAD+, but for you as a whole. Practice mindfulness, whether it’s through journaling, yoga, meditation, or another low-intensity activity that gives you the opportunity to slow down and reflect. 

Is NAD Well Tolerated?

For most healthy adults, NAD+ supplementation and IV therapy are tolerable when administered under medical supervision. Do note that because NAD+ can affect metabolism and cellular activity, supplementation may not be appropriate for everyone. Always check with your provider to determine if it’s a right fit for you.

Red Flags To Share With Us [Med list, pregnancy, chronic conditions]

Please keep in mind that NAD+ should be avoided in patients who currently have or recently had cancer. Your current medlist should be reviewed with your provider, especially if you’re on chemotherapy, immunosuppressants, or heart medications. 

Additionally, NAD+ supplementation is not recommended for use during pregnancy or breastfeeding.

Always review your health history with a qualified clinician before starting NAD+ therapy.

What Is the Function of NAD+?

NAD+ is an essential coenzyme in cellular metabolism, energy production, DNA repair, and regulation of many biological processes across the body. These processes influence aging, brain health, and inflammation.

How About Now?

How Often Should You Get NAD Injections?

Ultimately, NAD+ dosing does not have a one-size-fits-all schedule. This will vary on your body’s needs and should be evaluated with a qualified clinician.

Factors That Change Frequency

Your overall health goals (energy, recovery, anti-aging, cognitive support), Age and baseline NAD+ levels, Existing medical conditions or medications, How your body responds to initial treatments

Can NAD+ Boost Women’s Fertility or Help With IVF

Research on NAD+ and women’s fertility is emerging, but more must be conducted before any conclusive claims can be made. Some animal and laboratory studies suggest that it may support egg quality and mitochondrial health, which in turn could help with fertility, but we do not have enough clinical evidence to recommend it specifically for this purpose. 

Do You Prefer Saying Nicotinamide Adenine Dinucleotide or NAD+?

Typically, we refer to the coenzyme as NAD+ (the active oxidized form), as it is a simpler term that more people are familiar with.

Is NAD a Peptide?

Despite popular belief, NAD+ is not a peptide; it’s a coenzyme derived from niacin, also known as vitamin B3. Peptides are short chains of amino acids, while NAD+ is a nucleotide-based molecule that’s involved in cellular metabolism.

Is NAD Good For Longevity?

Research suggests that NAD+ is a key factor in healthy aging. Higher NAD+ levels in the body play a role in supporting DNA repair, mitochondrial health, and sirtuin activation – all of which are associated with improved cellular resilience. Human studies are ongoing for further findings with NAD+, but the early research is promising.

Final Friendly Reminder

“This information is for educational purposes only and should not substitute or replace medical advice from a provider, clinician, dietitian, or nutritionist. If you are curious about any of the content here, you can reach out to askthepharmacist@olympiapharmacy.com, and one of our clinical pharmacists will get back to you!”
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What Are the Sexual Benefits of L-Arginine?

A smiling woman is being embraced from behind by a man, both appearing happy and affectionate in a softly lit, indoor setting.

L-arginine is a naturally occurring amino acid that is known to play a role in several key functions in the human body, including immune support, antioxidant defense and cardiovascular health[1]. One of its most critical roles is serving as a precursor to nitric oxide (NO), which is a signaling molecule that helps regulate blood vessel dilation, circulation and cellular communication[1].

Because nitric oxide plays a central role in increasing blood flow, L-arginine has drawn growing interest for its potential to support sexual function in both men and women. This amino acid may help address multiple aspects of sexual performance and satisfaction through its role in vascular health. 

This blog explores what current research says about how L-arginine works in the body and its potential benefits for sexual health.

What is L-Arginine and How Does it Work in the Body?

L-arginine serves as the body’s raw material for producing NO, which acts as a vasodilator, expanding blood vessels to improve circulation[1]. This NO production is central to many biological functions, including the regulation of blood pressure, oxygen delivery and endothelial (blood vessel lining) health[1].

For sexual health, this mechanism matters. In men, nitric oxide may play a role in erectile function, as it may promote relaxation of penile arteries, allowing for increased blood flow to help achieve and maintain an erection[2]. In women, the improved blood circulation may help enhance genital sensitivity, lubrication and arousal[3].

In addition to its vascular benefits, L-arginine is involved in immune response, neurotransmitter regulation and metabolic function, including insulin signaling and glucose balance[1]. It also acts as a natural antioxidant, helping to neutralize free radicals and support vascular health, which may further influence sexual performance and satisfaction[1].

Potential Sexual Benefits for Men

L-arginine may offer specific benefits for men’s sexual health, especially for those experiencing mild to moderate erectile dysfunction (ED). Because of its role in nitric oxide production, L-arginine may help support vasodilation, or the widening of blood vessels, which may play a role in achieving and maintaining an erection[1].

This mechanism is particularly relevant for men with circulatory-related ED, often classified as arteriogenic ED. Research suggests that men with this type of ED may have lower blood levels of L-arginine compared to those without ED, suggesting that deficiency in these amino acids may contribute to impaired blood flow and erectile function[4].

L-arginine has been explored as a natural support option or adjunct for men who either don’t respond well to or prefer to avoid pharmaceutical solutions like PDE-5 inhibitors (e.g., sildenafil or tadalafil)[1]. Unlike PDE-5 inhibitors, which only preserve NO, L-arginine helps stimulate its production directly[1].

Research suggests that daily supplementation with L-arginine may improve several aspects of sexual function, including erectile quality, orgasmic function and overall satisfaction, when compared to placebo or no treatment[5]. While it may not replace prescription medication in severe cases, it appears to be a well-tolerated, low-risk option for many men.

Find Out More

L-Arginine and Sexual Health in Women

While much of the research on L-arginine and sexual health focuses on men, emerging studies suggest that women may also benefit from increased nitric oxide availability. Research suggests that L-arginine, especially when combined with other nutrients, may support improvements across multiple aspects of female sexual function, including desire, arousal, lubrication and satisfaction[3]. These benefits have been observed in women at various life stages, including premenopausal, perimenopausal and postmenopausal groups[3]

The menopausal transition is associated with a natural decline in estrogen and nitric oxide production, which can impair endothelial function[6] and reduce genital blood flow—key elements in arousal and sexual response. By supporting NO synthesis and vascular health, L-arginine may help address some of the physiological changes that contribute to decreased sexual satisfaction during and after menopause.

Preliminary research also suggests that L-arginine may offer benefits for women experiencing low libido or sexual dysfunction related to major depressive disorder (MDD),[7] a condition strongly associated with decreased sexual desire, lubrication and satisfaction[8].

Although many of these studies involved supplement blends, the consistent results suggest that L-arginine’s effect on vascular and endothelial function may be a key contributor. This could make it a supportive option for women experiencing age- or medication-related declines in sexual response.

A female doctor is speaking with a couple during a consultation. The doctor is wearing a white coat and a stethoscope, while the couple sits across from her holding hands.

When To Consider L-Arginine Supplementation

While L-arginine is naturally found in foods like poultry, fish, legumes and seeds, supplementation may be worth considering in certain situations, especially when circulation, vascular health or sexual function are impacted. You might benefit from adding L-arginine if you:

  • Experience mild to moderate erectile dysfunction and aren’t ready for oral ED meds or Trimix
  • Have a condition or are taking medication that impacts libido or arousal
  • Are seeking a supplement that may enhance genital sensitivity or orgasm through improved blood flow
  • Want to support sexual wellness without relying solely on pharmaceutical solutions

As always, speak with a healthcare provider before starting any new supplement, especially if you have underlying cardiovascular conditions or take blood pressure medications.

Start Your Journey

How Long Does It Take for L-Arginine To Work Sexually

With limited research available, there isn’t a definitive answer to how long it takes L-arginine to improve sexual function, and results may vary based on individual health factors. 

For men, preliminary research suggests that taking high daily doses of L-arginine for 3 months may support improvements in both self-reported erectile function and certain clinical measures of blood flow[9]. However, these findings were observed in a specific population and may not apply to all individuals. At this time, there is not enough clinical evidence to determine how long L-arginine may take to affect sexual function in women.

If you’re considering L-arginine, be sure to follow the product’s usage instructions carefully and avoid exceeding the recommended dosage. As with any supplement, it’s a good idea to consult your healthcare provider before starting a new regimen, especially if you have underlying health conditions or are taking medications.

What To Know About Side Effects

L-arginine is generally well tolerated, especially when used under medical guidance. However, like many supplements, it may cause side effects in some individuals, particularly at higher doses or when combined with other compounds. Possible side effects include[10]:

  • Bloating or abdominal discomfort
  • Nausea or vomiting
  • Diarrhea
  • Headaches
  • Dizziness or feeling lightheaded
  • Flushing or low blood pressure 

Rare but serious reactions, such as allergic responses or irregular heartbeat, have been reported, especially in individuals with heart conditions. If you experience any concerning symptoms, it’s important to stop taking the supplement and consult a healthcare provider immediately. 

To minimize side effects, be sure to follow your provider’s instructions. Taking L-arginine with food may also reduce digestive discomfort.

Support Sexual Wellness With Olympia Pharmacy’s L-Arginine Injections

Whether you’re navigating mild erectile concerns, changes in arousal,or simply looking for a more natural way to support sexual health, L-arginine may offer a well-tolerated option.

Olympia Pharmacy compounds L-arginine with purity and precision, designed to meet the needs of patients and providers seeking evidence-informed solutions for sexual wellness. All formulations are prepared under strict Current Good Manufacturing Practice (CGMP) standards and can be incorporated into a broader care plan.

For women, our topical sexual creams like Scream and Climax combine L-arginine with other active ingredients designed to enhance sensitivity and arousal through improved circulation.

Ready to get started? Contact us to learn how Olympia’s high-quality L-arginine injections and other supplements can help enhance your wellness protocols and support patient outcomes.

Connect With Our Team

Resources

1. Mega Obukohwo Oyovwi, Adedeji David Atere, Exploring the medicinal significance of L-arginine mediated nitric oxide in preventing health disorders [Internet]. Elsevier Masson; 2024 [cited 2025 Jul 14]. Available from: https://www.sciencedirect.com/science/article/pii/S2772417424000475#bib93 

2. Koolwal A, Manohar J. S, Rao TSS, Koolwal GD. l-arginine and Erectile Dysfunction. Journal of Psychosexual Health. 2019;1(1):37-43. Available from: https://journals.sagepub.com/doi/10.1177/2631831818822018

3. Cieri-Hutcherson NE, Jaenecke A, Bahia A, Lucas D, Oluloro A, Stimmel L, Hutcherson TC. Systematic Review of l-Arginine for the Treatment of Hypoactive Sexual Desire Disorder and Related Conditions in Women. Pharmacy (Basel). 2021 Mar 27;9(2):71. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC8103282/

4. Barassi, A., Corsi Romanelli, M.M., Pezzilli, R., Damele, C.A.L., Vaccalluzzo, L., Goi, G., Papini, N., Colpi, G.M., Massaccesi, L. and Melzi d’Eril, G.V. (2017), Levels of l-arginine and l-citrulline in patients with erectile dysfunction of different etiology. Andrology, 5: 256-261. Available from: https://onlinelibrary.wiley.com/doi/full/10.1111/andr.12293

5. Rhim HC, Kim MS, Park YJ, Choi WS, Park HK, Kim HG, Kim A, Paick SH. The Potential Role of Arginine Supplements on Erectile Dysfunction: A Systemic Review and Meta-Analysis. J Sex Med. 2019 Feb;16(2):223-234. Available from: https://pubmed.ncbi.nlm.nih.gov/30770070/

6. Moreau KL, Hildreth KL, Meditz AL, Deane KD, Kohrt WM. Endothelial function is impaired across the stages of the menopause transition in healthy women. J Clin Endocrinol Metab. 2012 Dec;97(12):4692-700. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC3513538/

7. Torkaman, P., Meybodi, A.M., Kheradmand, A. et al. Effect of l-arginine compared to placebo on sexual function in women with major depressive disorder: a randomized controlled trial. BMC Psychiatry 24, 358 (2024). Available from: https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-024-05781-5

8. Thakurta RG, Singh OP, Bhattacharya A, Mallick AK, Ray P, Sen S, Das R. Nature of sexual dysfunctions in major depressive disorder and its impact on quality of life. Indian J Psychol Med. 2012 Oct;34(4):365-70. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC3662135/

9. Menafra D, de Angelis C, Garifalos F, Mazzella M, Galdiero G, Piscopo M, Castoro M, Verde N, Pivonello C, Simeoli C, Auriemma RS, Colao A, Pivonello R. Long-term high-dose L-arginine supplementation in patients with vasculogenic erectile dysfunction: a multicentre, double-blind, randomized, placebo-controlled clinical trial. J Endocrinol Invest. 2022 May;45(5):941-961. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC8995264/

10. L-arginine benefits, uses & side effects [Internet]. Cleveland Clinic; 2025. Available from: https://my.clevelandclinic.org/health/drugs/22536-l-arginine

Will I Gain All the Weight Back After Stopping GLP-1 Medications?

A person standing with one foot on a digital bathroom scale placed on a wooden floor.

If you’ve reached your goal weight using GLP-1 medications, congratulations! That’s no small feat. But as you prepare to stop treatment, one big question looms:

Will I gain all the weight back after stopping GLP-1s?

The answer depends on what you do next.

While it’s true that some individuals experience weight regain after coming off GLP-1 therapy, it’s not inevitable. With the right tools and support, you can maintain your weight and protect the progress you’ve made.

Common Concerns About Weight Regain After GLP-1s

It’s very common to worry about gaining weight back after stopping GLP-1 medications. And research shows that for many people, some weight regain does happen. That’s because these medications work by reducing appetite and helping you feel full longer, so when you stop taking them, your hunger may return, and this can make it harder to stick to a lower-calorie routine.

Obesity is a long-term, chronic condition, and just like other chronic health issues, it often requires ongoing support. By understanding what factors contribute to weight fluctuations, you can take steps to maintain your progress and continue feeling your best. 

What Happens When You Stop GLP-1 Therapy?

GLP-1 medications, such as liraglutide, work by reducing appetite, slowing digestion and regulating blood sugar. But when the medication is discontinued, those effects gradually wear off. Some common challenges during this transition include:

Increased Hunger or Cravings

One of the first changes many people notice is an increase in appetite. Without the appetite-suppressing effect of GLP-1s, hunger cues can come back quickly and feel more intense. Some individuals may feel like they’re constantly hungry, especially if their body is trying to regain lost weight, a biological survival mechanism known as “weight set point theory. This rebound in appetite can lead to eating more calories than your body needs, causing weight to creep back up. 

Slower Metabolism

When you lose weight, especially if it happens quickly, your metabolism often slows down. This is partly because the body now requires fewer calories to maintain a lower weight, a phenomenon sometimes referred to as metabolic adaptation. Without the metabolic boost from GLP-1s, your energy expenditure may drop, making it easier to regain weight.

Loss of Focus on Lifestyle Changes

Sometimes, the reliance on medication unintentionally overshadows important habits like healthy eating and regular exercise. If patients haven’t spent time building healthy habits during their program, weight regain will be more likely when the medication is stopped.

Emotional Eating Triggers Returning

For many, GLP-1s helped take the emotional edge off food decisions by minimizing cravings and reducing reward-based eating. Once off the medication, old habits like stress snacking or eating out of boredom can creep back in, especially if emotional eating patterns were never fully addressed during treatment.

These shifts can make it easier to slip back into old habits and harder to maintain weight loss. But don’t panic. This is where having a solid, sustainable maintenance plan becomes essential.

8 Keys To Maintaining Weight Loss After Stopping GLP-1 Therapy

1. Keep Up Healthy Habits From Treatment

Reaching your goal weight is just the beginning. Now, it’s about sustaining the habits that got you there. Think back to the habits you developed while using GLP-1 medication. Were you eating smaller portions, cutting back on sugary drinks, planning meals or tracking your weight regularly? These behaviors played a key role in your success, and continuing them will help support long-term results.

It’s easy to celebrate your success by loosening the reins, but consistency is key for maintenance. Some people find using a food journal or an app to log meals and weight can keep them accountable during the transition off medication. 

2. Follow a Balanced, Satisfying Diet

Focus on a nutritious eating pattern you can stick with for the long run. That means building meals with a balance of lean proteins, high-fiber whole grains, healthy fats, fruits, and vegetables. These foods are rich in nutrients and help you feel full on fewer calories, which is important for weight maintenance.

Protein plays a key role in helping you feel satisfied and preserving muscle mass, especially after weight loss. But don’t forget that carbohydrates and fats are also important. Carbs provide the energy your body and brain need to function well, especially if you’re active. Healthy fats, such as those found in avocados, olive oil, nuts, and seeds, help support hormone health and keep you feeling full between meals.

As your body adjusts after weight loss, you may not need as much food as you did before. A lower body weight often means a slower metabolism, so portion control becomes more important. If you’re unsure how to structure meals or track your intake, working with a registered dietitian can provide helpful guidance that aligns with your needs.

3. Be Mindful of Hunger Signals

One of the biggest changes after GLP-1 therapy is the return of natural hunger cues. Because GLP-1s suppress appetite, many patients haven’t had to “tune in” to hunger or fullness in months.

Now’s the time to reestablish that connection with your body. Pay attention to physical hunger vs. emotional or situational eating. Try slowing down during meals, avoiding distractions like screens and stopping when you feel satisfied (not stuffed). It may take some practice, but mindful eating can be one of the most powerful tools for long-term weight control.

4. Stay Physically Active

Exercise is your ally in weight maintenance. In fact, research has shown that people who incorporate consistent exercise may maintain more weight loss after stopping GLP-1 therapy. One study found that patients who combined their weight-loss medication with a structured exercise routine were four times more likely to keep at least 10% of their weight off a year after stopping, compared to those who did not exercise.

Regular physical activity not only burns calories but also helps counteract the metabolic slowdown that can occur after weight loss. Both cardio (aerobic exercise) and strength training are beneficial, as cardio helps burn fat, while strength training builds muscle mass, which can in turn boost your resting metabolism.

You don’t need to train like an athlete. Even brisk walking, resistance training or moderate cardio a few times a week can help maintain your metabolism and muscle mass. The key is consistency and finding movement you enjoy so it becomes a sustainable part of your routine.

5. Prioritize Sleep

Don’t underestimate the power of good sleep for weight control. Inadequate sleep can disrupt hormones that regulate hunger and fullness (ghrelin and leptin), increasing your appetite. It also saps your willpower and energy, making it harder to exercise or resist junk food. One Mayo Clinic study found that people who slept too little and had free access to food ate more calories and gained more fat, especially around the belly​.

Think of sleep as part of your weight maintenance plan, just like diet and exercise. Strive for 7-9 hours of quality sleep per night. Keep a consistent sleep schedule and create a calming bedtime routine. 

6. Manage Stress

For many people, stress leads to emotional or mindless eating — reaching for comfort foods, snacking out of habit, or skipping meals and then overeating later. These behaviors can easily derail the healthy routines you built during GLP-1 treatment and lead to weight gain.

To keep your post-GLP-1 progress, adopt stress-reduction habits that work for you. This might be mindfulness meditation, deep breathing exercises, yoga, journaling or even just walking outside in nature. Staying socially connected with friends or support groups can also buffer stress. If you notice stress or emotional ups and downs affecting your eating, consider talking to a counselor or joining a weight maintenance support group. 

7. Track Your Progress and Patterns

Monitoring your weight isn’t about obsessing over the number on the scale. It’s about staying aware of small shifts so you can course-correct early if needed. Whether you prefer weekly weigh-ins, taking progress photos or journaling how you feel physically and emotionally, regular check-ins give you valuable insight into what’s working and what needs adjusting.

Many factors influence weight maintenance, and recognizing patterns can help you stay ahead of potential setbacks. If you’re unsure how to interpret those trends, consulting with your healthcare provider can provide added clarity and guidance. They can help identify whether changes are normal or signal a need for extra support, and suggest interventions that fit your goals.

8. Use Supportive Therapies to Bridge the Gap

When you stop GLP-1 medications, your body may still need support adjusting to its new “normal.” This is where targeted therapies like lipotropic and wellness injections may make a difference. These products are designed to support metabolism, boost energy and promote fat utilization, helping you maintain your weight without relying solely on diet and exercise. Think of it as a bridge between active weight loss and long-term maintenance, especially during the critical months right after stopping GLP-1 therapy.

How Can Lipotropic Injections Help with Weight Maintenance? 

Lipotropic injections are designed to aid in fat breakdown, aid your metabolism and support long-term weight management. They contain nutrients and amino acids that work together to help support your body’s fat metabolism and potentially enhance your energy levels. Here’s a closer look at the types of lipotropic injections offered by Olympia:

Lipo Mino Mix
A powerful blend of B vitamins, amino acids and fat-burning compounds designed to help maintain energy and metabolism. Includes B6, B1, B2, methionine, inositol and choline. Also available as Lipo Mino Mix C with added L-carnitine for enhanced fat-to-energy conversion.

Lipo Plus
Formulated for medically supervised weight management. Combines potent ingredients like B6, methionine, inositol and choline to help support metabolism.

Lipo Stat Plus / Lipo Stat Plus SF
Ideal for active individuals, this formula may support metabolism and energy using inositol, choline and B6. The SF version is a sulfa-free option.

MICC Injection
A concentrated injection designed to accelerate fat metabolism and increase energy levels. Includes methionine, inositol, choline and cyanocobalamin (B12).

Vitamin B12 Injections
Olympia offers three forms of B12: cyanocobalamin, hydroxocobalamin and methylcobalamin. Each may support metabolism, red blood cell formation and energy production. These may be helpful in offsetting fatigue and maintaining physical and mental performance during your weight maintenance phase.

L-Carnitine Injection
An amino acid derivative that may help convert stored fat into usable energy. L-carnitine may support endurance, recovery and overall fat metabolism.

Sermorelin
A growth hormone-releasing therapy that can aid in preserving lean muscle mass and supporting metabolism as you age. While not a direct weight loss solution, it may help support several metabolic functions tied to long-term weight control.

Vitamin D3 Injection
Vitamin D may play a role in hormone balance, bone health and potentially reducing body fat. Supplementing with D3 may help support your overall metabolic wellness after GLP-1 therapy.

Your Weight Loss Journey Isn’t Over — It’s Just Evolving

GLP-1 medications helped as you worked toward your goals. Now it’s time to protect the results you’ve achieved. Remember, obesity is a chronic, complex condition, and long-term success isn’t about willpower alone. It requires ongoing care, support and the right tools to stay on track.

Olympia’s full lineup of lipotropic and wellness injectables is designed to support your body through this next phase. These solutions may help aid metabolism, sustain energy and reinforce healthy habits as you transition off GLP-1s.

Talk to your provider or wellness clinic about incorporating Olympia’s post-GLP-1 support into your routine. With expert care, you can protect your progress and feel your best for the long haul.

Explore Olympia’s Weight Management Solutions

Resources

1. Ganipisetti VM, Bollimunta P. (2023). Obesity and Set-Point Theory [Updated April 25, 2023]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025–. Available from: https://www.ncbi.nlm.nih.gov/books/NBK592402/

2. Most J, Redman LM. (2020). Impact of calorie restriction on energy metabolism in humans. Experimental Gerontology, 133, 110875. https://doi.org/10.1016/j.exger.2020.110875

3. Jensen SBK, et al. (2024). Healthy weight loss maintenance with exercise, GLP-1 receptor agonist, or both combined followed by one year without treatment: A post-treatment analysis of a randomised placebo-controlled trial. eClinicalMedicine, 69, 102475. https://doi.org/10.1016/j.eclinm.2024.102475 

4. Malloy T. (2022, March 28). Lack of sleep increases unhealthy abdominal fat. Mayo Clinic News Network. https://newsnetwork.mayoclinic.org/discussion/lack-of-sleep-increases-unhealthy-abdominal-fat/

5. Kumar R, Rizvi MR, Saraswat S. (2022). Obesity and stress: A contingent paralysis. International Journal of Preventive Medicine, 13, 95. https://doi.org/10.4103/ijpvm.IJPVM_427_20

Can Oxidative Stress Be Reduced?

Illustration of human cells

Oxidative stress happens quietly, but its effects ripple through your entire system. Whether you’re battling fatigue, inflammation or simply trying to age well, oxidative stress could be working against you in the background.

Let’s break down what it is, why it matters and how you can reduce it.

What Is Oxidative Stress?

Oxidative stress occurs when the production of reactive oxygen species (ROS) or free radicals exceeds the body’s ability to neutralize them with antioxidants. These free radicals are unstable molecules that contain unpaired electrons. To stabilize themselves, they react with nearby molecules, damaging DNA, proteins, cell membranes and lipids in the process.

Illustration showing how a healthy cell becomes damaged by free radicals, leading to oxidative stress

What Causes Oxidative Stress?

While free radicals are a natural byproduct of cellular metabolism and immune responses, excessive levels can be harmful. Contributing factors include:

  • A diet high in sugar and processed fats[1]
  • Exposure to environmental toxins like air pollution, pesticides and heavy metals[2]
  • Cigarette smoke[3] and alcohol use[4]
  • Infections and chronic inflammation[5]
  • Intense or prolonged physical exertion[6
  • Psychological stress[7]

Biochemically, oxidative stress is marked by an imbalance between oxidants and antioxidants, disrupting cellular signaling, promoting inflammation and weakening mitochondrial function.[8] Over time, this imbalance can lead to cumulative molecular damage, a foundational factor in aging and disease progression.

Why Oxidative Stress Matters for Long-Term Health

The effects of oxidative stress are far-reaching. While the body has systems in place to repair damaged cells, persistent oxidative stress overwhelms those mechanisms, setting off a chain reaction of cellular dysfunction.

Chronic oxidative stress is linked to a wide range of diseases, including:

  • Cardiovascular disease: ROS damage endothelial cells lining blood vessels, promoting atherosclerosis and hypertension.[9]
  • Neurodegenerative disorders: Oxidative damage to neurons is a key driver in conditions like Alzheimer’s, Parkinson’s and ALS.[10]
  • Diabetes and insulin resistance: Oxidative stress impairs insulin signaling and worsens glycemic control.[10]
  • Cancer: DNA mutations caused by free radical damage may initiate or accelerate tumor development.[11]
  • Autoimmune conditions: Oxidative stress can trigger inflammatory pathways, contributing to immune dysregulation.[9]

Even outside of these conditions, oxidative stress contributes to fatigue, slower recovery, immune suppression and premature aging at the cellular level. Mitochondria, your body’s energy-producing organelles, are particularly vulnerable, which can result in reduced energy, brain fog and decreased physical performance.

How the Body Defends Itself

Your body is built to handle a certain amount of oxidative stress. It has a defense system made up of antioxidants, compounds that neutralize free radicals by giving them an electron, which stops them from damaging healthy cells.

Diagram showing how an antioxidant donates an electron to a free radical to stabilize it and prevent cellular damage

These antioxidants come from two main sources:

1. Your Body’s Natural Antioxidants

Your cells produce their own antioxidants to help protect against daily stress. These natural defenses work constantly to keep free radicals in check and maintain balance inside your cells.

2. Antioxidants from Food

You also get antioxidants from what you eat. Fruits, vegetables, nuts and whole grains are rich in nutrients that support your body’s defenses, including:

  • Vitamin C (found in citrus and bell peppers)
  • Vitamin E (found in nuts and seeds)
  • Selenium and zinc (found in seafood, eggs and legumes)
  • Plant compounds like flavonoids and polyphenols (found in colorful produce, teas and spices)

Together, these nutrients help your body recover from stress, fight inflammation and stay resilient.[12]

The problem comes when your body’s defense system can’t keep up, either because of poor nutrition, aging, chronic stress or exposure to toxins. That’s when oxidative stress builds up and starts causing damage at a deeper level.

In these cases, lifestyle changes or targeted therapies may be needed to restore the balance.

How to Reduce Oxidative Stress Naturally

While you can’t avoid oxidative stress completely, you can help your body manage it by building habits that support your natural defenses.

Here are some ways to lower your oxidative load:

1. Eat Antioxidant-Rich Foods

A diet full of colorful fruits and vegetables gives your body the nutrients it needs to fight free radicals. Focus on:

  • Leafy greens
  • Berries
  • Citrus fruits
  • Cruciferous vegetables like broccoli and cauliflower
  • Herbs and spices like turmeric and garlic

These foods are packed with vitamins, minerals and plant compounds that support cellular health.

2. Get Regular, Moderate Exercise

Movement helps boost circulation, reduce inflammation and support healthy metabolism. But more isn’t always better — overtraining can increase oxidative stress. Aim for consistent, moderate activity like walking, cycling or strength training a few times a week.

3. Prioritize Sleep

Your body does most of its repair work while you sleep. Poor or inconsistent sleep can increase inflammation and weaken antioxidant defenses.[13] Try to get 7–9 hours of quality sleep each night.

4. Manage Stress

Chronic emotional stress increases the production of free radicals and impairs antioxidant defenses. Stress-management tools like breathwork, stretching, meditation or time in nature can help lower your stress response and support balance.

5. Limit Exposure to Toxins

Avoiding cigarette smoke, excessive alcohol, heavily processed foods and environmental toxins can take pressure off your detox systems and reduce your body’s need to play defense.

Glutathione: A Targeted Defense

Two vials of glutathione 200 mg/ml from Olympia Pharmaceuticals.

Sometimes, even the healthiest habits aren’t enough, especially if you’re dealing with ongoing stress, fatigue, chronic illness or a high-demand lifestyle. In those cases, your body’s natural antioxidant supply may not be able to keep up.

That’s where supplemental glutathione can help.

Glutathione is one of the most powerful antioxidants your body makes. It plays a key role in:

  • Protecting cells from damage[14]
  • Supporting immune function[15]
  • Detoxification[15]

While your body does produce glutathione on its own, levels naturally decline with age, stress, poor diet or exposure to toxins. This can leave your cells more vulnerable to oxidative stress and slow down your ability to recover.

Why IV or IM Glutathione?

Absorption of oral glutathione can be inconsistent due to the range of factors that impact the digestive system, including stomach acid levels, enzyme activity, gut inflammation and individual differences in metabolism. That’s why IV (intravenous) or IM (intramuscular) glutathione is often preferred, especially for people who need faster or more complete support.

Olympia Pharmaceuticals offers high-quality glutathione for IV and IM use, available through licensed healthcare providers. It’s a simple way to help restore balance and protect your long-term health.

Final Takeaway

Oxidative stress is unavoidable, but that doesn’t mean you have to let it take control. By supporting your body with the right habits and solutions like IV or IM glutathione, you may restore balance, protect your health and recover with more resilience.

Talk to your provider about whether glutathione is right for you or reach out to Olympia Pharmaceuticals for more information.

Learn More About Glutathione

Resources

1. Martínez Leo EE, Meza Peñafiel A, Hernández Escalante VM, Cabrera Araujo ZM. Ultra-processed diet, systemic oxidative stress, and breach of immunologic tolerance. Nutrition. 2021;91-92:111419. doi:10.1016/j.nut.2021.111419.

2. Samet JM, Wages PA. Oxidative stress from environmental exposures. Curr Opin Toxicol. 2018;7:60-66. doi:10.1016/j.cotox.2017.10.008.

3. Aridgides DS, Mellinger DL, Armstrong DA, et al. Functional and metabolic impairment in cigarette smoke-exposed macrophages is tied to oxidative stress. Sci Rep. 2019;9:9624. doi:10.1038/s41598-019-46045-7.

4. Tsermpini EE, Plemenitaš Ilješ A, Dolžan V. Alcohol-Induced Oxidative Stress and the Role of Antioxidants in Alcohol Use Disorder: A Systematic Review. Antioxidants. 2022; 11(7):1374. https://doi.org/10.3390/antiox11071374

5. D’Aiuto F, Nibali L, Parkar M, Patel K, Suvan J, Donos N. Oxidative Stress, Systemic Inflammation, and Severe Periodontitis. Journal of Dental Research. 2010;89(11):1241-1246. doi:10.1177/0022034510375830

6. Cho S-Y, Chung Y-S, Yoon H-K, Roh H-T. Impact of Exercise Intensity on Systemic Oxidative Stress, Inflammatory Responses, and Sirtuin Levels in Healthy Male Volunteers. International Journal of Environmental Research and Public Health. 2022; 19(18):11292. https://doi.org/10.3390/ijerph191811292

7. Aschbacher K, O’Donovan A, Wolkowitz OM, et al. Good stress, bad stress and oxidative stress: insights from anticipatory cortisol reactivity. Psychoneuroendocrinology. 2013;38(9):1698-1708. doi:10.1016/j.psyneuen.2013.02.004.

8. Marí M, Morales A, Colell A, García-Ruiz C, Fernández-Checa JC. Mitochondrial glutathione, a key survival antioxidant. Antioxid Redox Signal. 2009;11(11):2685-2700. doi:10.1089/ARS.2009.2695

9. Rahman T, Hosen I, Islam M, Shekhar H. Oxidative stress and human health. Adv Biosci Biotechnol. 2012;3:997-1019. doi:10.4236/abb.2012.327123.

10. Reddy VP. Oxidative Stress in Health and Disease. Biomedicines. 2023;11(11):2925. Published 2023 Oct 29. doi:10.3390/biomedicines11112925

11. Sharifi-Rad M, Anil Kumar NV, Zucca P, et al. Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases. Front Physiol. 2020;11:694. Published 2020 Jul 2. doi:10.3389/fphys.2020.00694

12. Rahaman MM, Hossain R, Herrera-Bravo J, et al. Natural antioxidants from some fruits, seeds, foods, natural products, and associated health benefits: An update. Food Sci Nutr. 2023;11(4):1657-1670. Published 2023 Jan 13. doi:10.1002/fsn3.3217

13. Busler J, Grant L, Liao V, Lin A, Rahman S, Mahon P. 0130 Central and peripheral markers of oxidative stress and sleep in mood disorder: a pilot MR spectroscopy study. Sleep. 2022;45(Suppl 1):A58-A59. doi:10.1093/sleep/zsac079.128.

14. Kwon DH, Cha HJ, Lee H, et al. Protective Effect of Glutathione against Oxidative Stress-induced Cytotoxicity in RAW 264.7 Macrophages through Activating the Nuclear Factor Erythroid 2-Related Factor-2/Heme Oxygenase-1 Pathway. Antioxidants (Basel). 2019;8(4):82. Published 2019 Apr 1. doi:10.3390/antiox8040082

15. Novelli, A., & Bianchetti, A. (2022). Glutathione: pharmacological aspects and implications for clinical use. Geriatric Care, 8(2). https://doi.org/10.4081/gc.2022.10390

Top 5+ Longevity Supplements of 2025 (Injectables)

Looking to enhance your health and vitality with injectable longevity supplements? Here’s a straightforward guide to popular injectable supplements designed to support energy, metabolism, immunity, and overall wellness in 2025.

1. NAD+ Injectable

A bottle of Olympia Pharmacy's NAD+

NAD+ injectables deliver a coenzyme directly into your system, potentially supporting cellular energy, DNA health, and overall cellular function.

Possible Benefits:

Take the First Step Toward Healthy Aging

2. Lipo Mino C Injectable

Amber vial labeled "Olympia Pharmaceuticals Lipo-Mino-Mix-C"

Lipo Mino C combines Carnitine with essential nutrients in injectable form, optimizing absorption and potentially supporting immune health, collagen production, and antioxidant protection.

Possible Benefits:

  • Supports immune function
  • Promotes healthy skin and joints
  • Provides antioxidant protection

3. Sermorelin Injectable

A small, clear vial with a blue cap and label. The label reads, "Olympia Sermorelin Acetate Lyophilized Powder for Reconstitution Injection."

Sermorelin Injections stimulates your pituitary gland to naturally release growth hormone, which may aid muscle support, recovery, sleep quality, and general wellness.

Possible Benefits:

  • Supports muscle tone and body composition
  • Enhances sleep quality and recovery
  • Supports overall metabolic health

4. Glutathione Injectable

Glutathione is known for its antioxidant properties and ability to promote cellular health. Higher glutathione levels are associated with fewer illnesses, increased energy, and slower aging signs.

Possible Benefits:

  • Supports cellular health
  • Enhances antioxidant defenses
  • Encourages overall vitality and wellness

5. Vitamin D Injectable

A 30ml amber vial of medication. The vial has a black cap and label, which reads "Olympia Vitamin D3 - 50,000 IU/mL Injection. 1.25mg/mL."

Vitamin D may support anti-aging by potentially slowing down cellular aging processes. Studies suggest it can help preserve protective chromosome caps that shorten with age, potentially impacting age-related health risks. Vitamin D is essential for skin health and maintaining a healthy gut. Approximately 42% of adults in the US have a Vitamin D deficiency.

Possible Benefits:

  • Supports skin and gut health
  • Potentially slows cellular aging
  • Promotes overall wellness

6. MICC Injectable

Amber vial labeled "Olympia Pharmaceuticals MICC"

MICC combines methionine, inositol, choline, and cyanocobalamin (vitamin B12) into an injectable designed to support metabolism and energy. This may support longevity by promoting overall health and vitality, and a healthier lifestyle.

Possible Benefits:

  • Supports fat metabolism
  • Encourages overall energy levels
  • Assists liver function

7. L-Carnitine Injectable

Amber glass vial labeled "Olympia Pharmaceuticals L-Carnitine 500mg/ml," containing an injectable compound used to support fat metabolism and energy production.

L-Carnitine injectables support your body’s natural fat-burning processes, promoting metabolic and cardiovascular wellness. L-Carnitine also promotes longevity by improving recovery from oxidative stress and supporting mitochondrial function.

Possible Benefits:

  • Encourages energy production through fat metabolism
  • Supports cardiovascular health
  • Enhances physical performance and recovery

8. Methylcobalamin B12 Injectable

Amber vial labeled "Olympia Pharmaceuticals Methylcobalamin 5mg/ml," an injectable form of vitamin B12 commonly used to support energy, nervous system function, and red blood cell production.

Methylcobalamin (or methyl b12) is an active form of vitamin B12 that supports neurological wellness, mood stability, energy production, and heart health. While vitamin B12 is important for general health, there isn’t direct evidence linking it specifically to increased longevity. However, methylcobalamin supports healthy aging by contributing to key bodily functions essential for maintaining vitality over time.

Possible Benefits:

  • Supports cognitive and neurological function
  • Encourages stable energy and improved mood
  • Supports cardiovascular wellness and healthy blood cell formation

To wrap things up…

Injectable longevity supplements are designed to complement a lifestyle of good nutrition, regular exercise, and restful sleep. Ready to unlock your full wellness potential? Contact our specialists today and begin your journey toward enhanced vitality and longevity

Unlock Your Full Wellness Potential

Enclomiphene for Men: A Smarter Way to Restore Testosterone

Man in a blue polo shirt sits with hands folded while speaking with a healthcare provider holding a tablet and pen during a consultation.

Enclomiphene is gaining attention as a promising option for men looking to address low testosterone without the tradeoffs often associated with traditional testosterone replacement therapy (TRT). With its unique mechanism of action, this compound offers a new approach to hormone support, particularly for men who want to maintain reproductive health. 

In this blog, we’ll explore how enclomiphene works, how it compares to other solutions and what the latest research says about its benefits, side effects and long-term considerations.

What Is Enclomiphene?

Enclomiphene is an oral medication that may support natural testosterone production in men. It belongs to a class of drugs called selective estrogen receptor modulators (SERMs) and may be prescribed to men with secondary hypogonadism, which is a condition where the brain fails to signal the testes to produce adequate testosterone.

Rather than introducing external testosterone into the body, enclomiphene works by activating the body’s own hormone pathways, helping to restore testosterone levels through internal signaling rather than introducing external testosterone into the body[1].

Learn More

How Enclomiphene Works in Men

Enclomiphene may increase testosterone by acting on the hypothalamic-pituitary-gonadal (HPG) axis, the body’s natural hormone-regulating system[1]. Under normal conditions, estrogen signals the hypothalamus to reduce the release of gonadotropin-releasing hormone (GnRH) through a process called negative feedback. Enclomiphene blocks this signal by selectively binding to estrogen receptors in the hypothalamus, which can lead to an increase in GnRH secretion. [1].

GnRH then triggers the anterior pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH)[1]. LH prompts the testes to produce testosterone[2], while FSH supports sperm production[3]. This leads to a natural increase in testosterone levels, as well as maintenance of testicular function and sperm production.

Enclomiphene vs. Clomid

Clomiphene citrate (often referred to by its brand name, Clomid) is a medication made up of two chemical forms, or isomers: about 62% enclomiphene (trans-isomer) and 38% zuclomiphene (cis-isomer)[4]. Enclomiphene is the active component that stimulates testosterone production. In contrast, zuclomiphene has estrogen-like effects and a longer half-life, which may contribute to unwanted side effects over time[4]

Enclomiphene citrate is a purified version that only contains the active isomer (enclomiphene). By removing the estrogen-like component, it may help support testosterone production without the unwanted hormonal activity linked to zuclomiphene[4].

Research suggests that enclomiphene may increase testosterone levels comparably to clomiphene[5] but with fewer reported side effects. One study reported adverse events in 18.18% of men taking clomiphene, compared to just 3.45% of those on enclomiphene [5]. Men on enclomiphene reported experiencing lower rates of mood changes, low libido and fatigue. Additionally, estradiol levels rose substantially on clomiphene but remained stable with enclomiphene[6]. Estradiol is the most potent form of estrogen in the body, and while essential in small amounts, elevated levels in men may contribute to issues like erectile difficulty or disrupted sexual function[7][8].

​​Additionally, enclomiphene has been associated with better pregnancy outcomes compared to clomiphene in men seeking fertility support[6], suggesting it may be a more favorable option for those balancing hormone optimization with reproductive goals.

Enclomiphene vs. TRT (Testosterone Replacement Therapy)

Traditional testosterone replacement (TRT) therapies like injections, gels, cream, tablets and pellets work by delivering external testosterone to the body. While this may raise testosterone levels and improve symptoms like low libido, mood changes and muscle loss[9], it may come at the cost of fertility. That’s because TRT suppresses the HPG axis, which may reduce the body’s own production of key reproductive hormones (LH and FSH) and lead to lower sperm counts or even temporary infertility[10]. In fact, TRT has even been studied as a potential form of male contraception due to this effect[10].

Enclomiphene, on the other hand, may boost natural testosterone production by stimulating LH and FSH release. In contrast, men using topical testosterone gel saw decreases in LH and FSH and a reduction in sperm production[12]

Benefits of Enclomiphene for Men

Fertility-Friendly Option

Since research suggests that enclomiphene raises testosterone levels without negatively affecting sperm production, it may be a promising option for men who want to optimize their hormones while preserving their fertility. This makes it appealing for younger men or those hoping to start or grow their families in the future.

Improved Energy and Mood

Many men report noticeable improvements in energy, focus and mood once their testosterone levels return to a healthier range[13][14]. While individual responses can vary, restoring hormone balance often has a positive impact on daily motivation, cognitive sharpness and emotional well-being.

Start Your Journey Today

Is Enclomiphene FDA-Approved?

Enclomiphene is not approved by the U.S. Food and Drug Administration (FDA).  It is a prescription-only medication and should be used under the guidance of a licensed healthcare provider.

Although not FDA-approved, enclomiphene has been evaluated in several studies for men with secondary hypogonadism. Research to date suggests it is generally well tolerated, with no serious adverse events reported during short- to mid-term use.

Common Side Effects

Research suggests that enclomiphene is generally well tolerated, with a lower rate of side effects compared to clomiphene[15][11]. While serious reactions are rare, some men have reported mild to moderate symptoms, including[15][11]:

  • Headache
  • Abdominal discomfort
  • Mood changes (such as irritability or low mood)
  • Fatigue or decreased energy
  • Changes in libido
  • Mild elevation in estradiol levels

If you experience persistent mood swings, nausea, visual changes or any new symptoms while taking enclomiphene, it’s important to consult your provider. 

Long-Term Use Considerations

Early studies suggest that enclomiphene may be a well-tolerated option for short- to mid-term solution for hypogonadism, with no serious adverse events reported[16][15]. However, most trials to date have lasted only a few months, so its long-term effects remain less well understood.

While current evidence is encouraging, more research is needed to evaluate its impact over years of use, including effects on bone health, mood, metabolism and cardiovascular risk. Until those data are available, regular follow-up with lab testing and symptom tracking is important to evaluate response and adjust care as needed.

Who Should Consider Enclomiphene?

Enclomiphene may be a good option for men experiencing secondary hypogonadism. It’s well-suited for those who want to restore natural testosterone levels without compromising fertility. Because enclomiphene may stimulate the body’s hormone production instead of replacing testosterone externally (as traditional TRT does), it may be prescribed for men who:

  • Want to maintain or improve sperm production while improving low testosterone
  • Want to avoid testosterone gels or injections
  • Have symptoms of low testosterone but prefer a treatment option that supports natural hormone regulation

Signs You May Have Low Testosterone

Low testosterone can show up in different ways, and symptoms often vary depending on your age and overall health. Common signs include[17]:

  • Reduced sex drive or difficulty with erections
  • Fatigue, low motivation or lack of endurance
  • Brain fog or trouble concentrating
  • Loss of muscle mass or strength
  • Increased body fat or breast tissue development
  • Shrinking testicles or low sperm count (which may affect fertility)
  • Depressed mood or mood swings

If you’re noticing several of these symptoms, it may be worth getting your hormone levels checked. A licensed provider can help determine if enclomiphene is right for your specific needs.

Getting Started with Enclomiphene at Olympia Pharmacy

As interest in enclomiphene grows among men seeking hormone support without compromising fertility, providers need access to reliable formulations that align with patient goals.

Olympia Pharmacy compounds enclomiphene in a high-quality, oral format intended for use under the guidance of licensed healthcare professionals. All formulations follow strict CGMP practices to ensure consistency and performance.

Want to learn more about offering enclomiphene as part of your practice? Connect with our team to explore how Olympia’s premium compounded medications can support your needs.

Resources

1. [Internet]. [cited 2025 Jun 24]. Available from: https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C61745

2. Nedresky D, Singh G. Physiology, Luteinizing Hormone. [Updated 2022 Sep 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK539692/

3. Orlowski M, Sarao MS. Physiology, Follicle Stimulating Hormone. [Updated 2023 May 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK535442/

4. Gupta, M. C., & Khanna, J. (2018). Clomiphene citrate: the changing landscape. International Journal of Basic & Clinical Pharmacology, 7(8), 1437–1443. https://doi.org/10.18203/2319-2003.ijbcp20183011

5. J Kassab, G Saffati, L Lipshultz, M Khera, (094) Safety and Efficacy of Enclomiphene Compared to Clomiphene for Hypogonadal Men, The Journal of Sexual Medicine, Volume 21, Issue Supplement_1, February 2024, qdae001.090, https://doi.org/10.1093/jsxmed/qdae001.090

6. Kassab J, Torres-Anguiano J, Lindsey J, Gondokusumo J, Itani S, Jabin M, et al. MP43-13 ENCLOMIPHENE IS ASSOCIATED WITH HIGHER PREGNANCY RATES WHEN COMPARED TO CLOMIPHENE IN INFERTILE MEN WITH LOW TESTOSTERONE. Journal of Urology [Internet]. 2023 Apr 1 [cited 2025 Jun 25];209(Supplement 4):e606. Available from: https://doi.org/10.1097/JU.0000000000003289.13

7. Chen T, Wu F, Wang X, Ma G, Xuan X, Tang R, Ding S, Lu J. Different levels of estradiol are correlated with sexual dysfunction in adult men. Sci Rep. 2020 Jul 29;10(1):12660. doi: 10.1038/s41598-020-69712-6. PMID: 32728148; PMCID: PMC7391660.

8. Schulster M, Bernie AM, Ramasamy R. The role of estradiol in male reproductive function. Asian J Androl. 2016 May-Jun;18(3):435-40. doi: 10.4103/1008-682X.173932. PMID: 26908066; PMCID: PMC4854098.

9. Barbonetti A, D’Andrea S, Francavilla S. Testosterone replacement therapy. Andrology. 2020; 8: 1551–1566. https://doi.org/10.1111/andr.12774

10. Fink J, Ide H, Horie S. Management of Male Fertility in Hypogonadal Patients on Testosterone Replacement Therapy. Medicina (Kaunas). 2024 Feb 5;60(2):275. doi: 10.3390/medicina60020275. PMID: 38399562; PMCID: PMC10890669.

11. Rodriguez KM, Pastuszak AW, Lipshultz LI. Enclomiphene citrate for the treatment of secondary male hypogonadism. Expert Opin Pharmacother. 2016 Aug;17(11):1561-7. doi: 10.1080/14656566.2016.1204294. Epub 2016 Jul 4. PMID: 27337642; PMCID: PMC5009465.

12. Kim, E.D., McCullough, A. and Kaminetsky, J. (2016), Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement. BJU Int, 117: 677-685. https://doi.org/10.1111/bju.13337

13. Zitzmann M. Testosterone, mood, behaviour and quality of life. Andrology. 2020; 8: 1598–1605. https://doi.org/10.1111/andr.12867

14. Zitzmann, M. (2006). Testosterone and the brain. The Aging Male, 9(4), 195–199. https://doi.org/10.1080/13685530601040679

15. Saffati G, Kassab J, Orozco Rendon D, Hinojosa-Gonzalez DE, Kronstedt S, Lipshultz LI, Khera M. Safety and efficacy of enclomiphene and clomiphene for hypogonadal men. Transl Androl Urol. 2024 Sep 30;13(9):1984-1990. doi: 10.21037/tau-24-238. Epub 2024 Sep 24. PMID: 39434750; PMCID: PMC11491226.

16. Jed Kaminetsky, Michael Werner, Greg Fontenot, Ronald D. Wiehle, Oral Enclomiphene Citrate Stimulates the Endogenous Production of Testosterone and Sperm Counts in Men with Low Testosterone: Comparison with Testosterone Gel, The Journal of Sexual Medicine, Volume 10, Issue 6, June 2013, Pages 1628–1635, https://doi.org/10.1111/jsm.12116

17. Low testosterone (low T): Causes, symptoms & treatment [Internet]. 2025 [cited 2025 Jun 24]. Available from: https://my.clevelandclinic.org/health/diseases/15603-low-testosterone-male-hypogonadism

Does Oral NAD+ Work as Well as Injectable? Here’s What to Know

Female healthcare professional inspecting an IV drip, preparing for intravenous administration.

As NAD+ becomes more widely recognized for its role in energy production and healthy aging, more people are exploring supplements to support their cellular health. However, the way you take NAD+ can influence how well it works. NAD+ is available in oral and injectable forms. So how do you know whether oral or injectable NAD+ is the better choice for you? 

In this blog, we’ll break down the key differences between delivery methods, explore how NAD+ works in the body and highlight why injections may be preferred. 

What Is NAD+?

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell of the body. It plays a central role in cellular energy production, helping convert nutrients into the fuel your cells run on. 

Beyond energy production, NAD+ is also crucial for supporting DNA repair[1][2], regulating inflammation[2] and maintaining mitochondrial function[2]. Mitochondria — your cells’ energy centers — rely on adequate NAD+ levels to function optimally. When mitochondrial activity declines, it can lead to increased cellular damage and contribute to visible signs of aging[3]

Research also suggests that NAD+ is critical for DNA repair and cellular resilience after UV damage[1], which are key factors in preventing visible aging. 

How NAD Works in the Body

NAD+ helps your body generate energy by fueling mitochondria — the “powerhouses” of cells. It acts as a key electron carrier in metabolic reactions, allowing cells to turn food into ATP, the body’s main energy source. NAD+ also activates enzymes like sirtuins, which play roles in cellular stress response, inflammation control and metabolic regulation. Additionally, NAD+ helps maintain the stability of your DNA, which is critical for reducing the risk of mutations that can lead to premature aging and disease.

Why Supplement It?

As we age, NAD+ production slows and the molecule breaks down more quickly, leading to lower overall levels in the body. This drop is linked to greater susceptibility to age-related conditions like cognitive decline[4] and metabolic dysfunction[5]. Lower NAD+ levels are also associated with repair enzymes like PARP1 and sirtuins becoming less effective, allowing DNA damage and cellular stress to accumulate[1]. This contributes to reduced collagen production, chronic inflammation and the buildup of senescent cells (sometimes called “zombie cells”) that weaken the skin’s structure over time[1].

To address this, longevity and regenerative medicine researchers have increasingly focused on supplementing NAD+ and its precursors, including nicotinamide (NAM), nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). One area where this is already showing promise is skin health. Research suggests that boosting NAD+ levels, particularly through supplementation of NAM, can help repair sun-damaged skin and reduce the appearance of premature aging[6][7].

By maintaining NAD+ levels, the body may better manage energy production, cellular stress response and age-related cellular decline.

A vial labeled "NAD+" next to a filled syringe on a blue background.

Comparing Oral vs. Injectable NAD+

As interest in NAD+ therapy continues to grow, both oral and injectable forms are now commonly used for supplementation. While oral NAD+ supplements are widely available, many patients and providers prefer injectable formulations due to their enhanced bioavailability and more consistent results.

Absorption and Delivery Differences

Oral NAD+ supplements must pass through the gastrointestinal (GI) tract, where enzymatic breakdown and variable absorption can limit how much NAD+ actually reaches circulation[8]. Digestive efficiency, gut health and individual metabolism all influence oral bioavailability. Moreover, multiple studies have shown that oral NAD+ is poorly absorbed and does not significantly raise NAD+ levels in the plasma or tissues[9].

In contrast, injectable NAD+ bypasses the digestive system entirely, entering the bloodstream directly[8] for more immediate and efficient cellular uptake. This direct delivery route ensures the full dose reaches circulation without being degraded or lost in the gut. Currently, intravenous NAD+ infusion is the only recognized method for reliably increasing NAD+ levels[10]

Dosing Consistency

Injections offer a more controlled and consistent method of delivering NAD+. Oral NAD+ absorption can fluctuate significantly depending on the timing of administration, the presence of food in the digestive system, as well as an individual’s overall gut health. Injectable NAD+ allows practitioners to formulate precise dosing protocols with predictable plasma concentrations, making it easier to track response and adjust as needed.

Time to Effect

Many users and clinicians report that NAD+ injections act faster than oral forms. Because injectable NAD+ becomes bioavailable more rapidly, it may more quickly engage in cellular processes such as mitochondrial energy production, DNA repair and oxidative stress regulation. This can be especially beneficial for individuals seeking support for acute fatigue, high-performance recovery or age-related cellular stress.

Considering injectable NAD+ for your patients? Get started now

Why Patients and Providers Often Choose NAD+ Injections

Supports Energy and Recovery Routines

Injectable NAD+ is frequently integrated into wellness programs designed to support vitality, post-exertion recovery and healthy aging. Under provider supervision, NAD+ injections may be included in protocols addressing low energy, brain fog, stress response and general mitochondrial health. Because NAD+ is used in hundreds of enzymatic reactions throughout the body, particularly in tissues with high energy demands, replenishing NAD+ levels directly via injection may support a more robust and sustainable cellular response.

Convenient for Those With Absorption Concerns

For patients with compromised digestive function, such as those with inflammatory bowel conditions, post-bariatric surgery recovery or age-related malabsorption, oral NAD+ may not provide reliable results. In these cases, injectable NAD+ may offer a more dependable option by bypassing the GI tract altogether. It helps ensure that therapeutic doses reach systemic circulation without the variability introduced by digestion.

Why Choose Olympia Pharmacy’s NAD+ Injections?

At Olympia, we understand that consistent delivery matters, especially when supporting energy metabolism and high-demand cellular processes. That’s why we offer high-quality compounded NAD+ injections to licensed healthcare providers, prepared in our CGMP-compliant facility and backed by rigorous quality and sterility standards.

Olympia’s NAD+ injections are intended for use in professionally guided wellness protocols, where injectable delivery may be preferred for more dependable uptake. Whether addressing cellular stress, low energy or supporting overall vitality, Olympia’s compounded NAD+ products are formulated with precision and reliability in mind.

Close-up of gloved hands drawing liquid from a vial into a syringe, preparing an injection.

Why Injectable NAD+ May Offer a More Reliable Option

When your cells have the energy they need to function, everything works better — from brain clarity and focus to physical recovery and metabolic balance. NAD+, a compound naturally found in every cell, plays a central role in these processes by helping convert nutrients into usable energy and supporting cell repair systems.

For individuals with digestive challenges or absorption concerns, NAD+ injections may also offer a more dependable way to support NAD+ levels and cellular repair mechanisms, especially when included in a professionally managed wellness routine. Olympia’s NAD+ injections are designed with precision, purity and provider needs in mind.

Contact Us

Resources

1. Conlon NJ. The Role of NAD+ in Regenerative Medicine. Plast Reconstr Surg. 2022 Oct 1;150(4 Suppl ):41S-48S. doi: 10.1097/PRS.0000000000009673. Epub 2021 Sep 28. PMID: 36170435; PMCID: PMC9512238.

2. Braidy N, Liu Y. NAD⁺ therapy in age-related degenerative disorders: A benefit/risk analysis. Exp Gerontol. 2020 Jul;132:110831. doi: 10.1016/j.exger.2020.110831. Epub 2020 Jan 15. PMID: 31958672.

3. Brand MD, Orr AL, Perevoshchikova IV, Quinlan CL. The role of mitochondrial function and cellular bioenergetics in ageing and disease. Br J Dermatol. 2013 Jul;169 Suppl 2(0 2):1-8. doi: 10.1111/bjd.12208. PMID: 23786614; PMCID: PMC4321783.

4. Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021 Feb;22(2):119-141. doi: 10.1038/s41580-020-00313-x. Epub 2020 Dec 22. PMID: 33353981; PMCID: PMC7963035.

5. Schultz MB, Sinclair DA. Why NAD⁺ declines during aging: It’s destroyed. Cell Metab. 2016 Jun 14;23(6):965-966. doi: 10.1016/j.cmet.2016.05.022. PMID: 27304506.

6. Radenkovic D, Reason, Verdin E. Clinical Evidence for Targeting NAD Therapeutically. Pharmaceuticals (Basel). 2020 Sep 15;13(9):247. doi: 10.3390/ph13090247. PMID: 32942582; PMCID: PMC7558103.

7. Camillo L, Zavattaro E, Savoia P. Nicotinamide: A Multifaceted Molecule in Skin Health and Beyond. Medicina (Kaunas). 2025 Feb 1;61(2):254. doi: 10.3390/medicina61020254. PMID: 40005371; PMCID: PMC11857428.

8. Stielow M, Witczyńska A, Kubryń N, Fijałkowski Ł, Nowaczyk J, Nowaczyk A. The Bioavailability of Drugs-The Current State of Knowledge. Molecules. 2023 Dec 11;28(24):8038. doi: 10.3390/molecules28248038. PMID: 38138529; PMCID: PMC10745386.

9. She J, Sheng R, Qin ZH. Pharmacology and Potential Implications of Nicotinamide Adenine Dinucleotide Precursors. Aging Dis. 2021 Dec 1;12(8):1879-1897. doi: 10.14336/AD.2021.0523. PMID: 34881075; PMCID: PMC8612620.

10. Braidy N, Berg J, Clement J, Khorshidi F, Poljak A, Jayasena T, Grant R, Sachdev P. Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes. Antioxid Redox Signal. 2019 Jan 10;30(2):251-294. doi: 10.1089/ars.2017.7269. Epub 2018 May 11. PMID: 29634344; PMCID: PMC6277084.