What is TriMix?

Olympia Pharmacy is the national expert on TriMix injections, offering patients and physicians a wealth of information, instruction and training on the medication.

TriMix injections are a mixture of three drugs that provide an effective, low-cost treatment for men struggling with erectile dysfunction. It is an alternative treatment for men who cannot take, have not had good results with, or experience severe side effects from PDE5 Inhibitor tablets (Viagra®, Levitra®, Cialis®). TriMix injections are a medication that is very customized to the patient’s needs. Olympia will work together with the physician and patient to develop a formula that is most effective for the individual patient. TriMix injections offer a solution for ED that is:

  • Safe
  • Reliable
  • Fast Acting
  • Long-lasting
  • More affordable than oral medications
  • Not affected by alcohol consumption

TriMix medication provides longer and fuller erections that can last even through climax, allowing you to maintain and improve your sexual health!

An intracavernous injection is the most effective non-surgical treatment for ED, according to the American Urologic Association. Injections into the penis, unlike oral medications, trigger an automatic erection in less than 5 minutes.

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What is Erectile Dysfunction?

Erectile Dysfunction is sexual dysfunction characterized by the inability to develop or maintain an erection sufficient for intercourse. While erectile dysfunction can affect men of any age, it is most common in men over the age of 40. Studies have estimated that the number of men suffering from erectile dysfunction in the United States is over 30 million.

Symptoms and Causes

The inability to achieve or maintain an erection can affect a man at any time. It can happen once in a while, or more frequently and there can be many different causes. Common causes include:

  • Low Testosterone
  • Cardiovascular disease
  • Diabetes
  • Prostate issues
  • Depression
  • Anxiety
  • Nerve / Spinal Cord Damage
  • Effects of taking medications

Treatment Options

Olympia offers a wide range of treatments for erectile dysfunction. We compound many different forms of popular oral medications as well as an injectable medication, TriMix.

Oral Medications

  • Sildenafil (compare to Viagra) – Available in capsules
  • Vardenafil (compare to Levitra – Available in capsules and sublinguals (dissolve under tongue)
  • Tadalafil (compare to Cialis) – Available in capsules, sublinguals and rapid dissolve tablets

TriMix Benefits

Goals of TriMix Injection Treatment

The goal of our TriMix injection treatment plans is to provide a man with a reliable, easy to use, safe method of achieving and maintaining an erection suitable for sexual relations. Once you receive a prescription, or if you have additional questions, contact us.


TriMix injections are a mixture of three drugs that provides an effective, low-cost erectile dysfunction treatment. TriMix injection solution must be refrigerated between doses.

Download TriMix Storage Instructions

Alternative to Tablets

TriMix injections are an alternative to PDE5 Inhibitor tablets (Viagra®, Levitra®, Cialis®) and most commonly include the mixture of 3 drugs; phentolamine, papaverine and alprostadil. TriMix injections are especially useful when patients are unable to take PDE5 Inhibitors because they are taking nitrates, certain beta blockers, or experience severe side effects from the oral medications.

TriMix Dosage

The initial dose should be .05cc to .2cc depending on the patients level of ED. Wait 48 hours before increasing dosage. Increase by 0.025 cc to 0.050 cc until a satisfactory dose is reached. The maximum dose is 0.50 cc. Do not be discouraged by a poor result with the first few injections, as the initial dose should be kept low to avoid a prolonged erection. TriMix injection is a medication that is very customized to the patient’s needs. Olympia will work together with the physician and patient to develop a TriMix injection formula that is most effective for the individual patient.

Download TriMix Injection Instructions

To prescribe TriMix Injections

  • Download and print the TriMix Prescription Form
  • Fax the signed and completed prescription form to Olympia (407-673-1234).
  • Olympia will ship directly to the patient.

We support physicians and have over 35 years of compounding expertise. We provide custom formulation and custom dosing to fit your needs.

View Our Information For Physicians

For other inquiries including dosing information please call our physician hotline at 407-673-2222 or email us at sales@olympiapharmacy.com.

TriMix Injection Studies

A prospective randomized study to optimize the dosage of trimix ingredients and compare its efficacy and safety with prostaglandin E1 A total of 180 men complaining of ED and presenting sequentially to the Urology Outpatient Department, from July 2000 to December 2002 were prospectively randomized to nine study groups (T1–T9). All patients with ED for at least 6 months were eligible except patients with a history of priapism, sickle cell anemia or previous surgical treatment for ED. Each group of patients received one dose of Tx or 20 g PgE1 at a clinic visit and 1 week later received the alternative drug. The order of injection was randomized and the patients were blinded to the drugs and doses injected. In this design, each patient served as his own control. Data were collected at the end of the first visit and at the beginning and end of the second visit. At a third visit, further management was discussed.


Studies with TriMix® in Men Who Failed Phosphodiesterase Inhibitors Abstract

Introduction and Objective:

Trimix (papaverine, phentolamine and PGE1) has been prepared by compounding pharmacists and used for intracavernous injections. After mixing, the shelf life is limited and refrigeration is recommended. As an alternative, topical TriMix-gel® seemed more stable and easier to use, but the results were poor due to limited absorption. Recently, we evaluated a new TriMix-gel® for administration at the urethral meatus. In this report, Erection Hardness Scores (EHS) and penile rigidity studies were recorded after the gel on 42 men with mixed morbidities who failed with PDE5 oral agents.


Sixteen men were on antihypertensive meds, 12 had type II diabetes, eight had high cholesterol and six were post-radical prostatectomy. Ten men had comorbidities. Prior to the gel, an EHS was recorded for the experience with oral agents. The trimix active ingredients and 0.3ml of gel were maintained in separate interlocking syringes at room temperature until the time of use. The final preparation was completed by vigorous mixing between the interlocking syringes. The mixed gel was inserted painlessly into the urethral meatus and the patient massaged the outer glans for two minutes to promote absorption. There was no other form of stimulation. After the gel, an EHS was recorded for each patient. In addition, nine had measurement of buckling pressures and seven had rigiscans.


For all 42 patients (mean age 55.2 yrs) the EHS was recorded as one for the oral agents (penis was larger but not hard), but 22 of these patients actually had no increase in size. After the gel, the mean EHS was 2.2, but 11 patients had an EHS of 3 (26.1%) and six had a 4 (16.6%). Thus, 40.4% of the study group had erections that were sufficient for penetration. In those with an ESH of 4, the buckling pressure was >90mm Hg. The rigiscans provided real-time information about the gel response and documented some tumescence in all cases. In a comparison of 3 and 4 scores, oral agents vs. gel, X² = 10.0, df 1, p<0.001.


TriMix-gel may have several advantages over oral agents and intracavernous injections. The active ingredients and gel may be carried by the patient at room temperature. The shelf life is long because the active ingredients are mixed only at time of use. The interlocking syringes permit thorough mixing. Administration is painless and massage of the glans may enhance mucosal absorption. Even without stimulation by a partner or videos, these patients demonstrated statistical significant greater EHS with gel versus oral agents. These pilot data support the use of TriMix-gel for ED, but more prospective trials are needed.

The abstract has been published in the Journal of Urology Supplement, J. Urol. 179 (4): 431, 2008. Author Disclosure Information: Joel L. Marmar, M.D., Robert Wood Johnson Medical School at Camden NJ and the Department of Urology, Cooper University Hospital, Camden, NJ Thomas J. Harkins, M.A.., TriMix Laboratories, Cherry Hill, NJ John Riordan, M.D., Robert Wood Johnson Medical School at Camden NJ and the Department of Urology, Cooper University Hospital, Camden, NJ.

How to Get Started

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While our erectile dysfunction medications require a prescription from a licensed physician, following these steps will make the process as simple as possible.

  1. Download and print the TriMix Prescription Form
  2. Present the form to your physician (usually your family doctor or urologist).
  3. Physician faxes the completed form to Olympia Pharmacy. Olympia will ship medication directly to you.

Start feeling the Olympia difference.

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