TriMix & TriMix Injections

Everything You Need To Know About

TriMix Definition: TriMix is a common term used to describe a mixture of Papaverine, Phentolamine and Alprostadil (PGE). Each of these drugs produce a vasodilating effect when injected into the penis. The injection is done using a very small needle, inserted into the proper area along the shaft of the penis, so the drug mixture is delivered into the corpus cavernosum. The mixture of drugs causes the corpus cavernosum to relax, dilate and become filled with blood, producing an erection. TriMix therapy is recognized as a viable treatment for erectile dysfunction by the American Urological Society.

TriMix is generally an effective, low-cost treatment, especially for those patients who have not had good results, or experience moderate to severe side effects from PDE5 inhibitors, (Viagra®, Levitra®, Cialis®).

 TriMix injections offer a solution for ED that is:

  • – Safe
  • – Reliable
  • – Fast-acting
  • – Long-lasting
  • – More affordable than oral medications
  • – Not affected by alcohol consumption

TriMix medication can provide longer and fuller erections that may last through climax, allowing you to maintain and improve your sexual health! An intracavernous injection is the most effective non-surgical treatment for ED, according to the American Urologic Association. Penile injections, unlike most oral medications, can trigger an automatic erection in less than 5 minutes.

trimix injection
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What Is Erectile Dysfunction?

Erectile dysfunction is sexual dysfunction characterized by the inability to develop or maintain an erection sufficient for intercourse. While erectile dysfunction can affect men of any age, it is most common in men over the age of 40. Studies have estimated that the number of men suffering from erectile dysfunction in the United States is more than 30 million. Learn more about erectile dysfunction and penile injection medications today.

Symptoms and Causes

The inability to achieve or maintain an erection can affect a man at any time. It can happen once in a while, or more frequently, and there can be many different causes. Some common causes include:

  • Low testosterone
  • – Cardiovascular disease
  • – Diabetes
  • – Prostate issues
  • – Depression
  • – Anxiety
  • – Nerve/spinal cord damage
  • – Effects of taking medications

Treatment Options

Olympia compounds various forms of popular oral medications for erectile dysfunction, such as:

  • Sildenafil (compare to Viagra) – Available in capsules or rapid dissolve tablets (dissolve under tongue)
  • Vardenafil (compare to Levitra) – Available in capsules or rapid dissolve tablets (dissolve under tongue)
  • Tadalafil (compare to Cialis) – Available in capsules or rapid dissolve tablets (dissolve under tongue)

Olympia also offers more than 40 combinations of TriMix, a popular penile injection therapy medication. Our TriMix medications are backed by a full stability study as well as cGMP testing of every batch.

Want answers to your TriMix injection questions? Visit our TriMix FAQ page now:

See Our TriMix FAQs

TriMix Dosage

The initial dose should be .05cc to .2cc, depending on each patient’s level of ED. Wait 48 hours before increasing dosage. Increase by 0.025 cc to 0.050 cc until a satisfactory dose is reached. The maximum dose is 0.50 cc. Do not be discouraged by a poor result with the first few injections, as the initial dose should be kept low to avoid a prolonged erection. TriMix injection is a medication that is very customized to the patient’s needs. Olympia will work together with the physician and patient to develop a TriMix injection formula that is most effective for the individual patient.

Download TriMix Injection Instructions

To Prescribe TriMix Injections:

  • – Download and print the TriMix Prescription Form.
  • – Fax the signed and completed prescription form to Olympia (407-673-1234).
  • – Olympia will ship directly to the patient.

We support physicians and have more than 35 years of compounding expertise. We provide custom formulation and custom dosing to fit your needs.

View Our Information For Physicians

For other inquiries, including dosing information, please call our physician hotline at 407-673-2222 or email us at

Use this helpful video for complete instructions on how to properly inject TriMix medication.

How to Get Started

How to Get Started

We support physicians and have more than 35 years of compounding expertise. We provide custom formulation and custom dosing to fit your needs.

To prescribe TriMix injections for patients:

  1. Download and print the TriMix Prescription Form.
  2. Fill out and fax the signed prescription form to Olympia Pharmacy at 407-673-1234.
  3. Olympia will ship injections directly to the patient.
Download Form

How to Get Started

While our erectile dysfunction medications do require a prescription from a licensed physician, following these steps will make the process simple and easy:

  1. Download and print the TriMix Prescription Form.
  2. Present the form to your physician (usually your family doctor or urologist).
  3. Your physician will fax the completed form to Olympia Pharmacy. Then, Olympia will ship medication directly to you.
Buy TriMix

TriMix Benefits

Goals of TriMix Injection Treatment

The goal of our TriMix injection treatment plans is to provide men with a reliable, easy to use, safe method of achieving and maintaining an erection suitable for sexual relations. There are many benefits to using TriMix injections for ED, including: they’re safe, effective, easy to store, long lasting, easy to administer and more. Once you receive a prescription, or if you have additional questions, contact us.


TriMix injections are a mixture of three drugs that are designed to provide an effective, low-cost erectile dysfunction treatment. TriMix injection solution must be refrigerated between doses.

Download TriMix Storage Instructions

Alternative to Tablets

TriMix injections are an alternative to PDE5 Inhibitor tablets (Viagra®, Levitra®, Cialis®) and most commonly include the mixture of three drugs; phentolamine, papaverine and alprostadil. These penile injections can be especially useful when patients are unable to take PDE5 Inhibitors because they are taking nitrates, certain beta blockers, or experience severe side effects from the oral medications.

TriMix Injection Studies

For detailed information about TriMix injections and their results, read this TriMix study conducted by the International Journal of Impotence Research below.

Introduction and Objective:

Intracavernous injection of Trimix (Tx) is indicated for patients unsuitable for prostaglandin E1 (PgE1) injection due to lack of response, pain or cost. We believe that the ideal ratio of ingredient doses in Tx is yet to be found. We postulated that increasing the doses of individual drug components in an orderly manner would convey important data on penile hemodynamic response. Such information is needed to choose an effective and less costly alternative to PgE1 with least side effects. We set out to evaluate the impact of varying the ingredient dosage on response and short-term safety of Tx compared with PgE1. We prospectively randomized 180 consecutive patients with erectile dysfunction into nine equal groups and each group received a different dose of Tx, namely phentolamine (1 mg) plus one dose of PgE1 (2.5, 5 or 10 μg) and one dose of papaverine (5, 10 or 20 mg). Each patient was injected with 20 μg PgE1 and one dose of Tx in two clinic visits 1 week apart. Following injection, duplex ultrasound of cavernous arteries and axial rigidometry were carried out. Patients ranked the quality of erection, estimated overall satisfaction and reported time to detumescence and side effects. Patients’ mean age was 50.5±11.7 y with underlying organic condition in 91.1%. We set out to evaluate, by means of an acute, prospective, randomized, single blind study, the various dose combinations of Tx versus PgE1 20 μg using both subjective and objective end points.


We think that the ideal ratio of ingredient doses in Tx is yet to be found. The effect of increasing individual drug components on penile response is not known. Such information is needed to choose an effective and less costly alternative to PgE1 with least side effects.


In spite of oral drug therapy for ED, there is a considerable number of candidates for self-injection therapy. These include patients who do not respond to or have a contraindication for PDE-5 inhibitor treatment. In addition, some patients prefer the rigidity provided by injections. In patients undergoing ICI therapy and given the option to try sildenafil, 36.2% decided to use injections most of the time or at least sporadically. The association of multiple vasoactive drugs produces a full erectile response in more than 90% of patients. In nonresponders to doses as high as 40 μg PGE1, Tx combination produced a response in 31%. The cost of the medication is another important issue where Tx has an advantage.